[2-Methyl-4-(trifluoromethoxy)phenyl]boronic acid | CAS No. 850033-39-5
[2-Methyl-4-(trifluoromethoxy)phenyl]boronic acid
Basic Information
CAS Number
850033-39-5
Molecular Formula
C8H8BF3O3
Molecular Weight
219.96 g/mol
AD
Basic Physical Properties
Boiling Point
280.8°C at 760 mmHg
Density
1.36
Flash Point
123.6°C
Refractive Index
1.464
Safety Information
View Safety InformationHazard Statement
Synonyms & References
English
- 2-Methyl-4-(trifluoromethoxy)phenylboronic acid
- [2-methyl-4-(trifluoromethoxy)phenyl]boronic acid
- 2-Methyl-4-trifluoromethoxyphenylboronic acid
- Boronic acid,B-[2-methyl-4-(trifluoromethoxy)phenyl]-
- PC7578
MDL Number
MFCD09475816
Customs Code
2931900090
FAQ
What are the physical and chemical properties of (2-Methyl-4-(trifluoromethoxy)phenyl)boronic acid (CAS: 850033-39-5)?
(2-Methyl-4-(trifluoromethoxy)phenyl)boronic acid (CAS: 850033-39-5) is a white crystalline solid with a molecular weight of approximately 320.11 g/mol. It has a low solubility in water but is soluble in organic solvents such as dichloromethane and acetonitrile. This compound is relatively stable but reactive towards strong bases and reducing agents. It is used in various synthetic applications due to its reactivity in Suzuki couplings.
How is (2-Methyl-4-(trifluoromethoxy)phenyl)boronic acid (CAS: 850033-39-5) typically synthesized?
(2-Methyl-4-(trifluoromethoxy)phenyl)boronic acid (CAS: 850033-39-5) is commonly synthesized through a multistep process involving the protection of the phenolic hydroxyl group, followed by the introduction of the trifluoromethoxy group, and finally the generation of the boronic acid functionality. This synthesis typically requires catalysts like palladium(II) acetate and ligands such as Xantphos, with high selectivity and yields.
What industries use (2-Methyl-4-(trifluoromethoxy)phenyl)boronic acid (CAS: 850033-39-5)?
(2-Methyl-4-(trifluoromethoxy)phenyl)boronic acid (CAS: 850033-39-5) is primarily used in the pharmaceutical and polymer industries for the preparation of medicinally active compounds and functional polymers. It is also utilized in semiconductor manufacturing for its stability and reactivity under various conditions.
What precautions should be taken when handling (2-Methyl-4-(trifluoromethoxy)phenyl)boronic acid (CAS: 850033-39-5)?
When handling (2-Methyl-4-(trifluoromethoxy)phenyl)boronic acid (CAS: 850033-39-5), appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats should be worn. This compound should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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