[2-Methyl-4-(trifluoromethoxy)phenyl]boronic acid(CAS: 850033-39-5)

(2-Methyl-4-(trifluoromethoxy)phenyl)boronic acid (CAS: 850033-39-5) is a white crystalline solid with a molecular weight of approximately 320.11 g/mol. It has a low solubility in water but is soluble in organic solvents such as dichloromethane and acetonitrile. This compound is relatively stable but reactive towards strong bases and reducing agents. It is used in various synthetic applications due to its reactivity in Suzuki couplings.

(2-Methyl-4-(trifluoromethoxy)phenyl)boronic acid (CAS: 850033-39-5) is commonly synthesized through a multistep process involving the protection of the phenolic hydroxyl group, followed by the introduction of the trifluoromethoxy group, and finally the generation of the boronic acid functionality. This synthesis typically requires catalysts like palladium(II) acetate and ligands such as Xantphos, with high selectivity and yields.

(2-Methyl-4-(trifluoromethoxy)phenyl)boronic acid (CAS: 850033-39-5) is primarily used in the pharmaceutical and polymer industries for the preparation of medicinally active compounds and functional polymers. It is also utilized in semiconductor manufacturing for its stability and reactivity under various conditions.

When handling (2-Methyl-4-(trifluoromethoxy)phenyl)boronic acid (CAS: 850033-39-5), appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats should be worn. This compound should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.