(2-Fluoro-5-formylphenyl)boronic acid

Basic Information

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CAS Number

352534-79-3

Molecular Formula

C7H6BFO3

Molecular Weight

167.93 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

168-171°C

Boiling Point

360.2 ℃ at 760 mmHg

Density

1.33

Flash Point

171.7℃

Refractive Index

1.524

SMILES

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B(C1=C(C=CC(=C1)C=O)F)(O)O

InChI

InChI=1S/C7H6BFO3/c9-7-2-1-5(4-10)3-6(7)8(11)12/h1-4,11-12H

InChIKey

SQSWYWCEKCVQEA-UHFFFAOYSA-N

LogP

-0.6819999999999999

Topological Polar Surface Area

57.53 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

165

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Air Sensitive

Synonyms & References

English

CS-W016044
2-Fluoro-5-formylphenyl
AB13486
SY009436
DTXSID60376834
2-Fluoro-5-formylphenylboronicacid
J-509440
2-Fluoro-5-formylphenylboronic acid
352534-79-3
MFCD03095100
AKOS006344442
3-BORONO-4-FLUOROBENZALDEHYDE
BP-10230
EN300-7367754
SCHEMBL1711479
2-fluoro-5-formylbenzeneboronic acid
FT-0644492
AS-12307
2-fluoro-5-formylphenyl boronic acid
(2-fluoro-5-formylphenyl)boronic acid
(2-fluoranyl-5-methanoyl-phenyl)boronic acid
A822685
SQSWYWCEKCVQEA-UHFFFAOYSA-N
2-Fluoro-5-formylphenylboronic acid, AldrichCPR
2-Fluoro-5-formylbenzeneboronic acid
2-fluoro-3-formylbenzenboronic acid
Boronicacid, (2-fluoro-5-formylphenyl)- (9CI)
2-fluoro-5-formylphenylboronic acid

MDL Number

MFCD03095100

Customs Code

2931900090

FAQ

What are the physical and chemical properties of (2-Fluoro-5-formylphenyl)boronic acid (CAS: 352534-79-3)?

(2-Fluoro-5-formylphenyl)boronic acid is a white crystalline solid with a molecular weight of approximately 228.11 g/mol. It has a melting point around 128-129°C. The compound is soluble in organic solvents like methanol and ethanol but slightly soluble in water. It exhibits moderate reactivity, particularly towards nucleophilic substitution reactions, and shows basic behavior due to the presence of the boronic acid moiety.

How is (2-Fluoro-5-formylphenyl)boronic acid (CAS: 352534-79-3) typically synthesized?

(2-Fluoro-5-formylphenyl)boronic acid can be synthesized through a multistep process. A common method involves the coupling of 5-formyl-2-fluorophenol with boronic acid derivatives using an appropriate catalyst, such as tetrakis(triphenylphosphine)palladium(0), in the presence of a base like triethylamine. The reaction typically yields a high purity product with good selectivity and yield.

What industries use (2-Fluoro-5-formylphenyl)boronic acid (CAS: 352534-79-3)?

(2-Fluoro-5-formylphenyl)boronic acid is primarily used in pharmaceuticals for the synthesis of drug intermediates, as well as in the field of organic chemistry for various reactions. It also finds applications in the development of sensors and semiconductors due to its unique chemical properties and reactivity.

What precautions should be taken when handling (2-Fluoro-5-formylphenyl)boronic acid (CAS: 352534-79-3)?

When handling (2-Fluoro-5-formylphenyl)boronic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to minimize exposure. In case of spill, immediately clean up using appropriate absorbent materials and dispose of them according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and disposal procedures.