(2-Fluoro-5-formylphenyl)boronic acid(CAS: 352534-79-3)

(2-Fluoro-5-formylphenyl)boronic acid is a white crystalline solid with a molecular weight of approximately 228.11 g/mol. It has a melting point around 128-129°C. The compound is soluble in organic solvents like methanol and ethanol but slightly soluble in water. It exhibits moderate reactivity, particularly towards nucleophilic substitution reactions, and shows basic behavior due to the presence of the boronic acid moiety.

(2-Fluoro-5-formylphenyl)boronic acid can be synthesized through a multistep process. A common method involves the coupling of 5-formyl-2-fluorophenol with boronic acid derivatives using an appropriate catalyst, such as tetrakis(triphenylphosphine)palladium(0), in the presence of a base like triethylamine. The reaction typically yields a high purity product with good selectivity and yield.

(2-Fluoro-5-formylphenyl)boronic acid is primarily used in pharmaceuticals for the synthesis of drug intermediates, as well as in the field of organic chemistry for various reactions. It also finds applications in the development of sensors and semiconductors due to its unique chemical properties and reactivity.

When handling (2-Fluoro-5-formylphenyl)boronic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood to minimize exposure. In case of spill, immediately clean up using appropriate absorbent materials and dispose of them according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and disposal procedures.