Ethyl 3-amino-5-chloro-2-pyridinecarboxylate

Basic Information

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CAS Number

27330-35-4

Molecular Formula

C8H9ClN2O2

Molecular Weight

200.63 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

345.9°C at 760 mmHg

Flash Point

163°C

Refractive Index

1.573

SMILES

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CCOC(=O)C1=C(C=C(C=N1)Cl)N

InChI

InChI=1S/C8H9ClN2O2/c1-2-13-8(12)7-6(10)3-5(9)4-11-7/h3-4H,2,10H2,1H3

InChIKey

KYZPCGKVPOZMIB-UHFFFAOYSA-N

LogP

1.4939

Topological Polar Surface Area

65.21000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

189

Synonyms & References

English

NSC-151928
FT-0687465
SCHEMBL8692342
MFCD10566235
SB36328
SY105411
Ethyl 3-amino-5-chloropicolinate
DTXSID20302573
Ethyl3-amino-5-chloropicolinate
NSC151928
27330-35-4
AKOS015996067
ethyl 3-amino-5-chloropyridine-2-carboxylate
CS-0151828
F14069
A850862
DS-4244
3-Amino-5-chloro-pyridine-2-carboxylic acid ethyl ester
KYZPCGKVPOZMIB-UHFFFAOYSA-N
2-Pyridinecarboxylicacid, 3-amino-5-chloro-, ethyl ester
Ethyl 3-ami-5-chloropicolinate
3-amino-5-chloro-pyridine-2-carboxylic acid ethyl ester
AC1L6CC1
AC1Q64N4
ANW-71206
BH823
CTK4F9498
Ethyl-3-amino-5-chlorpicolinat
SureCN8692342
NSC 151928
AK104565

MDL Number

MFCD10566235

FAQ

What are the physical and chemical properties of Ethyl 3-amino-5-chloro-2-pyridinecarboxylate (CAS: 27330-35-4)?

Ethyl 3-amino-5-chloro-2-pyridinecarboxylate (CAS: 27330-35-4) is a crystalline compound with a molecular weight of approximately 235.67 g/mol. It has a low solubility in water but is soluble in organic solvents. The compound is moderately reactive, particularly with bases and nucleophiles. It forms colorless crystals and is stable under normal conditions.

How is Ethyl 3-amino-5-chloro-2-pyridinecarboxylate (CAS: 27330-35-4) typically synthesized?

Ethyl 3-amino-5-chloro-2-pyridinecarboxylate is typically synthesized via the reaction of 5-chloro-2-pyridinecarboxylic acid with ethylamine in the presence of a base like triethylamine. The reaction yields the desired amino compound with good selectivity and high yield. This method is commonly used in the synthesis of pharmaceutical intermediates.

What industries use Ethyl 3-amino-5-chloro-2-pyridinecarboxylate (CAS: 27330-35-4)?

Ethyl 3-amino-5-chloro-2-pyridinecarboxylate (CAS: 27330-35-4) is primarily used in the pharmaceutical and chemical industries as an intermediate for the synthesis of drugs and other organic compounds. It is also utilized in polymer chemistry for the development of advanced materials.

What precautions should be taken when handling Ethyl 3-amino-5-chloro-2-pyridinecarboxylate (CAS: 27330-35-4)?

When handling Ethyl 3-amino-5-chloro-2-pyridinecarboxylate (CAS: 27330-35-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Use a fume hood to minimize exposure to vapors. Spills should be carefully cleaned up using absorbent materials, and the area should be ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.