5-Bromo-2-chlorobenzoyl chloride

Basic Information

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CAS Number

21900-52-7

Molecular Formula

C7H3BrCl2O

Molecular Weight

253.91 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

281.4°C at 760 mmHg

SMILES

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C1=CC(=C(C=C1Br)C(=O)Cl)Cl

InChI

InChI=1S/C7H3BrCl2O/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H

InChIKey

TZIQQJRRMJWMDI-UHFFFAOYSA-N

LogP

3.4815000000000014

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

163

Safety Information

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Hazard Statement

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

5-bromo-2-chlorobenzoyl chloride
Benzoyl chloride, 5-bromo-2-chloro-
5-bromo 2-chloro benzoyl chloride
5-BROMO-2-CHLORO-BENZOYL CHLORIDE
2-chloro-5-bromobenzoic acid chloride
2-chloro-5-bromo-benzoyl chloride
5-Brom-2-chlor-benzoylchlorid
5-bromo-2-chlorobenzoic acid chloride
SY063656
5-Bromo-2-chloro-benzoylchloride
EN300-239811
MFCD03208978
DTXSID80373603
AMY31112
5-bromo-2-chloro benzoyl chloride
AKOS009476110
STR10324
F2190-0072
5-Bromo-2-chloro-benzoyl chloride
21900-52-7
SCHEMBL18163

MDL Number

MFCD03208978

Customs Code

2916399090

FAQ

What are the physical and chemical properties of 5-Bromo-2-chlorobenzoyl chloride (CAS: 21900-52-7)?

5-Bromo-2-chlorobenzoyl chloride (CAS: 21900-52-7) is a crystalline solid with a molecular weight of approximately 249.02 g/mol. It has a low solubility in water but is soluble in common organic solvents like dichloromethane, acetone, and ethanol. This compound is reactive, particularly towards nucleophiles, making it useful in various chemical transformations. It is stable under normal conditions but should be stored away from moisture to prevent hydrolysis.

How is 5-Bromo-2-chlorobenzoyl chloride (CAS: 21900-52-7) typically synthesized?

5-Bromo-2-chlorobenzoyl chloride is typically synthesized via a multi-step process involving the bromination and chlorination of benzene, followed by acylation. This process often requires the use of a phase transfer catalyst and generates high yields. The exact method can vary, but common solvents like dichloromethane are used, and the product is isolated by recrystallization.

What industries use 5-Bromo-2-chlorobenzoyl chloride (CAS: 21900-52-7)?

5-Bromo-2-chlorobenzoyl chloride (CAS: 21900-52-7) finds application in the pharmaceutical, polymer, and chemical synthesis industries. It is used as an intermediate in the synthesis of drugs, polymers, and other organic compounds. Its reactivity makes it valuable for producing functionalized organic molecules with specific properties.

What precautions should be taken when handling 5-Bromo-2-chlorobenzoyl chloride (CAS: 21900-52-7)?

When handling 5-Bromo-2-chlorobenzoyl chloride (CAS: 21900-52-7), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions.