L-Threonyl-L-glutamine

Basic Information

View in Editor

CAS Number

96337-79-0

Molecular Formula

C9H17N3O5

Molecular Weight

247.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Density

1.367±0.06 g/cm3 (20 ºC 760 Torr),

SMILES

View in Editor

C[C@H]([C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)O)N)O

InChI

InChI=1S/C9H17N3O5/c1-4(13)7(11)8(15)12-5(9(16)17)2-3-6(10)14/h4-5,7,13H,2-3,11H2,1H3,(H2,10,14)(H,12,15)(H,16,17)/t4-,5+,7+/m1/s1

InChIKey

BWUHENPAEMNGQJ-ZDLURKLDSA-N

LogP

-2.470599999999998

Topological Polar Surface Area

155.73999999999998 Å²

Hydrogen Bond Donor/Acceptor

7 / 8

Synonyms & References

English

L-Glutamine,L-threonyl-
Thr-Gln
5-amino-2-[(2-amino-3-hydroxybutanoyl)amino]-5-oxopentanoic acid
H-THR-GLN-OH
L-Glutamine, N2-L-threonyl- (ZCI)
L
L-Threonyl-L-glutamine (ACI)
112: PN: WO2011146121 PAGE: 116 claimed sequence
3: PN: WO2013073706 SEQID: 19 claimed sequence
438: PN: WO2005081628 SEQID: 440 claimed protein
605: PN: EP2071334 SEQID: 645 claimed protein
605: PN: WO2009077864 SEQID: 645 claimed protein

MDL Number

MFCD00057941

Customs Code

2924199090

FAQ

What are the physical and chemical properties of L-Threonyl-L-glutamine (CAS: 96337-79-0)?

L-Threonyl-L-glutamine is a crystalline compound with a molecular weight of approximately 308.34 g/mol. It is slightly soluble in water and exhibits good solubility in common organic solvents like ethanol. The compound is moderately reactive and can undergo hydrolysis under acidic conditions. It has a melting point of 195-197°C.

How is L-Threonyl-L-glutamine (CAS: 96337-79-0) typically synthesized?

L-Threonyl-L-glutamine is typically synthesized through solid-phase peptide synthesis (SPPS). The key steps involve coupling threonine to glutamine using a suitable coupling agent, followed by deprotection and cleavage from the resin. Commonly used coupling agents include Fmoc (fluorenylmethyloxycarbonyl) and HBTU (2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate).

What industries use L-Threonyl-L-glutamine (CAS: 96337-79-0)?

L-Threonyl-L-glutamine is primarily used in the pharmaceutical industry for research and development of therapeutic peptides. It is also utilized in polymer chemistry for the synthesis of functional polymers with specific properties. Additionally, it has potential applications in sensor technology and semiconductor manufacturing due to its reactivity and specific chemical functionality.

What precautions should be taken when handling L-Threonyl-L-glutamine (CAS: 96337-79-0)?

When handling L-Threonyl-L-glutamine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a fume hood to minimize exposure to the air. Spills should be handled by carefully removing the material using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.