L-Threonyl-L-glutamine(CAS: 96337-79-0)

L-Threonyl-L-glutamine is a crystalline compound with a molecular weight of approximately 308.34 g/mol. It is slightly soluble in water and exhibits good solubility in common organic solvents like ethanol. The compound is moderately reactive and can undergo hydrolysis under acidic conditions. It has a melting point of 195-197°C.

L-Threonyl-L-glutamine is typically synthesized through solid-phase peptide synthesis (SPPS). The key steps involve coupling threonine to glutamine using a suitable coupling agent, followed by deprotection and cleavage from the resin. Commonly used coupling agents include Fmoc (fluorenylmethyloxycarbonyl) and HBTU (2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate).

L-Threonyl-L-glutamine is primarily used in the pharmaceutical industry for research and development of therapeutic peptides. It is also utilized in polymer chemistry for the synthesis of functional polymers with specific properties. Additionally, it has potential applications in sensor technology and semiconductor manufacturing due to its reactivity and specific chemical functionality.

When handling L-Threonyl-L-glutamine, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a fume hood to minimize exposure to the air. Spills should be handled by carefully removing the material using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.