3-Chloro-2-methoxypyridine-5-boronic acid

Basic Information

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CAS Number

942438-89-3

Molecular Formula

C6H7BClNO3

Molecular Weight

187.39 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

337.4℃/760mmHg

Density

1.40

SMILES

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B(C1=CC(=C(N=C1)OC)Cl)(O)O

InChI

InChI=1S/C6H7BClNO3/c1-12-6-5(8)2-4(3-9-6)7(10)11/h2-3,10-11H,1H3

InChIKey

LOLPLMDQLOJSDH-UHFFFAOYSA-N

LogP

-0.5766000000000001

Topological Polar Surface Area

62.58 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

149

Synonyms & References

English

3-Chloro-2-methoxypyridine-5-boronic acid
(5-chloro-6-methoxypyridin-3-yl)boronic acid
5-chloro-6-methoxypyridin-3-ylboronic acid
Boronic acid, B-(5-chloro-6-methoxy-3-pyridinyl)-
(5-CHLORO-6-METHOXY-3-PYRIDYL)BORONIC ACID
3-Chloro-2-Methoxypyridine-5-BoronicAcid
PubChem11125
5-CHLORO-6-METHOXYPYRIDIN-3-YL-3-BORONIC ACID
LOLPLMDQLOJSDH-UHFFFAOYSA-N
FCH849664
B-(5-Chloro-6-methoxy-3-pyridinyl)boronic acid (ACI)
5-Chloro-6-methoxypyridin-3-ylboronicacid
5-Chloro-6-methoxypyridine-3-boronic acid
MFCD04972386
DB-010559
SY024396
AC-33464
AS-39091
AKOS006295705
J-501569
AB20959
SCHEMBL1811195
BORONIC ACID, B-(5-CHLORO-6-METHOXY-3-PYRIDINYL)-
(5-CHLORO-6-METHOXYPYRIDIN-3-YL)BORONIC ACID
EN300-7374787
942438-89-3
CS-0046219
3-Chloro-2-methoxypyridine-5-boronic acid, AldrichCPR
3-CHLORO-2-METHOXYPYRIDINE-5-BORONIC ACID
5-Chloro-6-methoxypyridine-3-boronic Acid
b-(5-chloro-6-methoxy-3-pyridinyl)boronic acid

MDL Number

MFCD04972386

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 3-Chloro-2-methoxypyridine-5-boronic acid (CAS: 942438-89-3)?

3-Chloro-2-methoxypyridine-5-boronic acid has a crystalline form with a molecular weight of approximately 221.02 g/mol. It is slightly soluble in water but soluble in organic solvents like methanol and ethanol. It is a reactive compound, particularly in its electrophilic and boronic acid functionalities, making it suitable for various synthetic applications.

How is 3-Chloro-2-methoxypyridine-5-boronic acid (CAS: 942438-89-3) typically synthesized?

3-Chloro-2-methoxypyridine-5-boronic acid is typically synthesized through the boronation of 3-chloro-2-methoxypyridine using pinacol borane (H3P(OC(CH3)2)2) as the boronating agent. This reaction proceeds with high selectivity and good yield under mild conditions, often requiring a Lewis acid catalyst such as copper(II) acetate to enhance reactivity.

What industries use 3-Chloro-2-methoxypyridine-5-boronic acid (CAS: 942438-89-3)?

3-Chloro-2-methoxypyridine-5-boronic acid is used in the pharmaceutical industry for the synthesis of various drug molecules. It is also utilized in the polymer industry as an additive for enhancing material properties and in the semiconductor industry for the fabrication of electronic devices due to its boron-containing functionality.

What precautions should be taken when handling 3-Chloro-2-methoxypyridine-5-boronic acid (CAS: 942438-89-3)?

When handling 3-Chloro-2-methoxypyridine-5-boronic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. Handle in a fume hood to avoid inhalation of vapors. In case of spill, use suitable absorbent materials and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.