3-Chloro-2-methoxypyridine-5-boronic acid(CAS: 942438-89-3)

3-Chloro-2-methoxypyridine-5-boronic acid has a crystalline form with a molecular weight of approximately 221.02 g/mol. It is slightly soluble in water but soluble in organic solvents like methanol and ethanol. It is a reactive compound, particularly in its electrophilic and boronic acid functionalities, making it suitable for various synthetic applications.

3-Chloro-2-methoxypyridine-5-boronic acid is typically synthesized through the boronation of 3-chloro-2-methoxypyridine using pinacol borane (H3P(OC(CH3)2)2) as the boronating agent. This reaction proceeds with high selectivity and good yield under mild conditions, often requiring a Lewis acid catalyst such as copper(II) acetate to enhance reactivity.

3-Chloro-2-methoxypyridine-5-boronic acid is used in the pharmaceutical industry for the synthesis of various drug molecules. It is also utilized in the polymer industry as an additive for enhancing material properties and in the semiconductor industry for the fabrication of electronic devices due to its boron-containing functionality.

When handling 3-Chloro-2-methoxypyridine-5-boronic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves and safety goggles. Handle in a fume hood to avoid inhalation of vapors. In case of spill, use suitable absorbent materials and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.