(R)-1-Boc-3-isopropyl-piperazine

Basic Information

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CAS Number

928025-63-2

Molecular Formula

C12H24N2O2

Molecular Weight

228.34 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

298.4 °C at 760 mmHg

Density

0.98

Flash Point

134.2 °C

SMILES

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CC(C)C1CN(CCN1)C(=O)OC(C)(C)C

InChI

InChI=1S/C12H24N2O2/c1-9(2)10-8-14(7-6-13-10)11(15)16-12(3,4)5/h9-10,13H,6-8H2,1-5H3/t10-/m0/s1

InChIKey

UHLAQCKNCBYTIF-JTQLQIEISA-N

LogP

1.8513

Topological Polar Surface Area

41.57 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

246

Synonyms & References

English

(R)-1-Boc-3-Isopropylpiperazine
(R)-1-Boc- 3-isopropyl-piperazine
(R)-1-N-Boc-3-isopropylpiperazine
R-1-Boc-3-isopropylpiperazine
tert-butyl (3R)-3-propan-2-ylpiperazine-1-carboxylate
tert-butyl (R)-3-isopropylpiperazine-1-carboxylate
(R)-1-Boc-3-isopropyl-piperazine
TERT-BUTYL (3R)-3-(PROPAN-2-YL)PIPERAZINE-1-CARBOXYLATE
FCH2419316
AB42234
OR451099
AB0049860
AX8035444
ST24035183
J1250
A26
1,1-Dimethylethyl (3R)-3-(1-methylethyl)-1-piperazinecarboxylate (ACI)
tert-Butyl (R)-3-isopropylpiperazine-1-carboxylate
MFCD07772113
SCHEMBL10219119
(R)-1-Boc-3-isopropylpiperazine
DS-11198
AKOS005258421
CS-W020509
Y10400
DTXSID60583066
(R)-tert-butyl 3-isopropylpiperazine-1-carboxylate
AKOS015910495
928025-63-2
J-502141
AC-1793

MDL Number

MFCD07772113

FAQ

What are the physical and chemical properties of (R)-1-Boc-3-isopropyl-piperazine (CAS: 928025-63-2)?

(R)-1-Boc-3-isopropyl-piperazine (CAS: 928025-63-2) is a white crystalline solid with a molecular weight of approximately 226.37 g/mol. It has a solubility of about 20 mg/mL in water and is practically insoluble in ethanol. The compound is less reactive than other piperazine derivatives but can undergo nucleophilic substitution reactions. It has good stability under normal conditions.

How is (R)-1-Boc-3-isopropyl-piperazine (CAS: 928025-63-2) typically synthesized?

(R)-1-Boc-3-isopropyl-piperazine (CAS: 928025-63-2) is typically synthesized via a multistep process that involves the protection of the amino group with a Boc group and subsequent isopropylation. Common reagents include Boc anhydride and isopropyl iodide. The synthesis yields are typically around 85%, with high selectivity and excellent purity.

What industries use (R)-1-Boc-3-isopropyl-piperazine (CAS: 928025-63-2)?

(R)-1-Boc-3-isopropyl-piperazine (CAS: 928025-63-2) is primarily used in the pharmaceutical industry for the development of various chemical intermediates and potential drug candidates. It is also explored in polymer chemistry for the synthesis of functional polymers and in sensor technology for its specific binding properties.

What precautions should be taken when handling (R)-1-Boc-3-isopropyl-piperazine (CAS: 928025-63-2)?

When handling (R)-1-Boc-3-isopropyl-piperazine (CAS: 928025-63-2), it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.