Levocetirizine amide

Basic Information

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CAS Number

909779-33-5

Molecular Formula

C21H26ClN3O2

Molecular Weight

387.91 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1CN(CCN1CCOCC(=O)N)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl

InChI

InChI=1S/C21H26ClN3O2/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)25-12-10-24(11-13-25)14-15-27-16-20(23)26/h1-9,21H,10-16H2,(H2,23,26)/t21-/m1/s1

InChIKey

LVJDQBJDVOYDLA-OAQYLSRUSA-N

LogP

2.5488999999999997

Topological Polar Surface Area

58.8 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

443

Synonyms & References

English

1AH2JG4B9H
2-[2-[4-[(R)-(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetamide
Levocetirizine amide
(R)-2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide
Acetamide, 2-(2-(4-((R)-(4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
(R)-2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetamide (Cetirizine Impurity
Unii-1AH2JG4B9H
2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetamide (ACI)
SCHEMBL3847601
2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetamide
LEVOCETIRIZINE AMIDE [USP-RS]
Levocetirizine Amide; (R)-2-(2-{4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl}ethoxy)acetamide; Acetamide, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
2-?[2-?[4-?[(R)?-?(4-?Chlorophenyl)?phenylmethyl]?-?1-?piperazinyl]?ethoxy]?-acetamide
909779-33-5
G87697
UNII-1AH2JG4B9H
CS-0166215

FAQ

What are the physical and chemical properties of Levocetirizine amide (CAS: 909779-33-5)?

Levocetirizine amide (CAS: 909779-33-5) is a white to off-white crystalline powder. Its molecular weight is approximately 271.27 g/mol. It has a low solubility in water but is more soluble in organic solvents. Chemically, it is moderately reactive towards bases and is stable in acidic conditions. It undergoes hydrolysis under basic conditions and can react with nucleophiles.

How is Levocetirizine amide (CAS: 909779-33-5) typically synthesized?

Levocetirizine amide (CAS: 909779-33-5) is synthesized via amidation of levocetirizine with a suitable amine. The reaction is typically catalyzed by a coupling agent like HATU and is carried out in a polar aprotic solvent such as N,N-Dimethylformamide (DMF). The process is selective, with high yield and good purity.

What industries use Levocetirizine amide (CAS: 909779-33-5)?

Levocetirizine amide (CAS: 909779-33-5) is primarily used in the pharmaceutical industry for manufacturing antihistamine drugs. It is also applied in the chemical industry for its reactivity in various organic reactions. Additionally, it can be utilized in polymer and sensor applications due to its chemical properties.

What precautions should be taken when handling Levocetirizine amide (CAS: 909779-33-5)?

When handling Levocetirizine amide (CAS: 909779-33-5), wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation. Follow safe storage procedures, storing it in a cool, dry place away from direct sunlight. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.