8-Methoxy-5-quinolinesulfonyl chloride

Basic Information

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CAS Number

90429-62-2

Molecular Formula

C10H8ClNO3S

Molecular Weight

257.7 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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COC1=C2C(=C(C=C1)S(=O)(=O)Cl)C=CC=N2

InChI

InChI=1S/C10H8ClNO3S/c1-15-8-4-5-9(16(11,13)14)7-3-2-6-12-10(7)8/h2-6H,1H3

InChIKey

CDUVKSFUNYBONL-UHFFFAOYSA-N

LogP

2.1708999999999996

Topological Polar Surface Area

56.26 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

341

Synonyms & References

English

FT-0762429
F91946
A917127
AKOS000131870
CS-0248386
90429-62-2
8-methoxyquinoline-5-sulfonyl chloride
VS-01560
8-Methoxy-5-quinolinesulfonyl chloride
8-Methoxyquinoline-5-sulphonyl chloride
SCHEMBL1332026
8-methoxyquinoline-5-sulfonylchloride
MFCD02752892
EN300-39712
8-methoxy-5-quinolinesulfonyl chloride, AldrichCPR
DTXSID00394310
5-Quinolinesulfonylchloride, 8-methoxy-
8-Methoxyquinoline-5-sulfonyl chloride
8-METHOXYQUINOLINE-5-SULPHONYL CHLORIDE
chloro(8-methoxy(5-quinolyl))sulfone

MDL Number

MFCD02752892

FAQ

What are the physical and chemical properties of 8-Methoxy-5-quinolinesulfonyl chloride (CAS: 90429-62-2)?

8-Methoxy-5-quinolinesulfonyl chloride is a white crystalline solid with a molecular weight of 274.07 g/mol. It has a high solubility in organic solvents like dichloromethane and methylene chloride. Chemically, it is reactive and forms stable derivatives with nucleophiles. It is also susceptible to hydrolysis and requires storage under dry conditions.

How is 8-Methoxy-5-quinolinesulfonyl chloride (CAS: 90429-62-2) typically synthesized?

8-Methoxy-5-quinolinesulfonyl chloride is synthesized through the condensation of 5-quinolinesulfonyl chloride with methanol under basic conditions. The reaction involves the use of a catalyst such as potassium carbonate, followed by purification of the product through recrystallization. The yield is generally good, and the method is selective and scalable.

What industries use 8-Methoxy-5-quinolinesulfonyl chloride (CAS: 90429-62-2)?

8-Methoxy-5-quinolinesulfonyl chloride is primarily used in the pharmaceutical industry for the synthesis of intermediates and final drug products. It also finds applications in the polymer industry for modifying polymer properties, in sensor technology for chemical sensing, and in electronic materials for semiconductor applications.

What precautions should be taken when handling 8-Methoxy-5-quinolinesulfonyl chloride (CAS: 90429-62-2)?

When handling 8-Methoxy-5-quinolinesulfonyl chloride, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be carefully cleaned up using absorbent materials, and the area should be washed with water. Always consult the Safety Data Sheet (SDS) for detailed handling and storage instructions.