8-Methoxy-5-quinolinesulfonyl chloride(CAS: 90429-62-2)

8-Methoxy-5-quinolinesulfonyl chloride is a white crystalline solid with a molecular weight of 274.07 g/mol. It has a high solubility in organic solvents like dichloromethane and methylene chloride. Chemically, it is reactive and forms stable derivatives with nucleophiles. It is also susceptible to hydrolysis and requires storage under dry conditions.

8-Methoxy-5-quinolinesulfonyl chloride is synthesized through the condensation of 5-quinolinesulfonyl chloride with methanol under basic conditions. The reaction involves the use of a catalyst such as potassium carbonate, followed by purification of the product through recrystallization. The yield is generally good, and the method is selective and scalable.

8-Methoxy-5-quinolinesulfonyl chloride is primarily used in the pharmaceutical industry for the synthesis of intermediates and final drug products. It also finds applications in the polymer industry for modifying polymer properties, in sensor technology for chemical sensing, and in electronic materials for semiconductor applications.

When handling 8-Methoxy-5-quinolinesulfonyl chloride, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation. Spills should be carefully cleaned up using absorbent materials, and the area should be washed with water. Always consult the Safety Data Sheet (SDS) for detailed handling and storage instructions.