4-(6-Isocyanato-2-pyridinyl)morpholine

Basic Information

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CAS Number

884507-15-7

Molecular Formula

C10H11N3O2

Molecular Weight

205.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Boiling Point

127 °C

SMILES

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C1COCCN1C2=CC=CC(=N2)N=C=O

InChI

InChI=1S/C10H11N3O2/c14-8-11-9-2-1-3-10(12-9)13-4-6-15-7-5-13/h1-3H,4-7H2

InChIKey

RYYZXDNHAQDJTI-UHFFFAOYSA-N

LogP

0.8855000000000001

Topological Polar Surface Area

54.790000000000006 Å²

Hydrogen Bond Donor/Acceptor

0 / 5

Complexity

247

Safety Information

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Hazard Statement

Synonyms & References

English

AMY39770
RYYZXDNHAQDJTI-UHFFFAOYSA-N
4-(6-Isocyanatopyridin-2-yl)morpholine
SCHEMBL1025434
A902284
FT-0761018
884507-15-7
J-513618
DTXSID80594497
4-(6-Isocyanatopyrid-2-yl)morpholine
Morpholine,4-(6-isocyanato-2-pyridinyl)-
4-(6-isocyanatopyridin-2-yl)morpholine
4-(6-ISOCYANATOPYRIDIN-2-YL)MORPHOLINE, TECH
4-(6-Isocyanatopyrid-2-yl)Morpholine, Tech.

MDL Number

MFCD08435861

FAQ

What are the physical and chemical properties of 4-(6-Isocyanato-2-pyridinyl)morpholine (CAS: 884507-15-7)?

4-(6-Isocyanato-2-pyridinyl)morpholine is a crystalline solid with a molecular weight of approximately 202.18 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Reactively, it is highly reactive due to the presence of the isocyanate group, which can participate in various types of chemical reactions. This compound is stable under normal conditions but requires careful handling to avoid decomposition or reaction with air and moisture.

How is 4-(6-Isocyanato-2-pyridinyl)morpholine (CAS: 884507-15-7) typically synthesized?

4-(6-Isocyanato-2-pyridinyl)morpholine is typically synthesized via the reaction of morpholine with 6-aminopyridine in the presence of a suitable amine scavenger. The process involves the formation of an isocyanate intermediate, followed by its reaction with morpholine. The yield is generally high, and the reaction is conducted under basic conditions to ensure good selectivity and yield. Common solvents include DMF or DMSO, and the reaction is monitored using thin-layer chromatography (TLC) to ensure completion.

What industries use 4-(6-Isocyanato-2-pyridinyl)morpholine (CAS: 884507-15-7)?

4-(6-Isocyanato-2-pyridinyl)morpholine is primarily utilized in the pharmaceutical and chemical industries due to its reactivity and unique chemical structure. It is used as an intermediate in the synthesis of various pharmaceutical compounds, especially those requiring specific functional groups. Additionally, it can be used in the development of certain polymers and materials, where its unique properties can be beneficial.

What precautions should be taken when handling 4-(6-Isocyanato-2-pyridinyl)morpholine (CAS: 884507-15-7)?

When handling 4-(6-Isocyanato-2-pyridinyl)morpholine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a fume hood to minimize exposure to the air. Spills should be cleaned up immediately using appropriate absorbents, and the area should be well-ventilated. In case of skin contact, wash the affected area with copious amounts of water. For ingestion, seek medical attention immediately. Safety data sheets (SDS) should always be referenced for specific handling instructions and emergency procedures.