3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine | CAS No. 877397-71-2
3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine
Basic Information
CAS Number
877397-71-2
Molecular Formula
C13H11Cl2FN2O
Molecular Weight
301.15 g/mol
AD
Chemical Classification
Basic Physical Properties
Density
1.400
Synonyms & References
English
- (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine
- (R)-3-(1-(2,6-Dichloro-3-fluorophenyl)-ethoxy)pyridin-2-amine
- 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine
- 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-2-pyridinamine (ACI)
- (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine
- 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine
- 3-[[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]pyridin-2-amine
MDL Number
MFCD18207060
Customs Code
2933399090
FAQ
What are the physical and chemical properties of 3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine (CAS: 877397-71-2)?
3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine is a crystalline compound with a molecular weight of approximately 417.04 g/mol. It has a high solubility in organic solvents like DMSO and moderate solubility in water. The compound is relatively stable but can react with bases to form the corresponding amine salts. Its reactivity is influenced by its electrophilic aromatic ring and the electron-withdrawing substituents.
How is 3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine (CAS: 877397-71-2) typically synthesized?
3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine can be synthesized via a multi-step process involving the formation of an intermediate phenol, which is then reacted with ethoxy pyridine. The synthesis typically uses catalytic palladium in the presence of a bases such as sodium carbonate. The yield is generally around 75-85%, and the method is selective and efficient.
What industries use 3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine (CAS: 877397-71-2)?
3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine is primarily used in the pharmaceutical industry for drug development due to its specific chemical structure. It may also find applications in the semiconductor industry as a component in certain electronic materials.
What precautions should be taken when handling 3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine (CAS: 877397-71-2)?
Proper handling of 3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine requires the use of personal protective equipment (PPE) including gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up with appropriate absorbent materials, and the area should be thoroughly washed down. Always refer to the safety data sheet (SDS) for specific handling instructions and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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