3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine(CAS: 877397-71-2)

3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine is a crystalline compound with a molecular weight of approximately 417.04 g/mol. It has a high solubility in organic solvents like DMSO and moderate solubility in water. The compound is relatively stable but can react with bases to form the corresponding amine salts. Its reactivity is influenced by its electrophilic aromatic ring and the electron-withdrawing substituents.

3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine can be synthesized via a multi-step process involving the formation of an intermediate phenol, which is then reacted with ethoxy pyridine. The synthesis typically uses catalytic palladium in the presence of a bases such as sodium carbonate. The yield is generally around 75-85%, and the method is selective and efficient.

3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine is primarily used in the pharmaceutical industry for drug development due to its specific chemical structure. It may also find applications in the semiconductor industry as a component in certain electronic materials.

Proper handling of 3-[(1R)-1-(2,6-dichloro-3-fluoro-phenyl)ethoxy]pyridin-2-amine requires the use of personal protective equipment (PPE) including gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up with appropriate absorbent materials, and the area should be thoroughly washed down. Always refer to the safety data sheet (SDS) for specific handling instructions and emergency procedures.