(5-Amino-2-nitrophenyl)methanol

Basic Information

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CAS Number

77376-03-5

Molecular Formula

C7H8N2O3

Molecular Weight

168.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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C1=CC(=C(C=C1N)CO)[N+](=O)[O-]

InChI

InChI=1S/C7H8N2O3/c8-6-1-2-7(9(11)12)5(3-6)4-10/h1-3,10H,4,8H2

InChIKey

VHFDIPNKJJLFLN-UHFFFAOYSA-N

Complexity

169

Synonyms & References

English

CS-0312383
77376-03-5
SCHEMBL2766494
DTXSID30531099
(5-Amino-2-nitrophenyl)methanol
5-Amino-2-nitrobenzyl alcohol
VHFDIPNKJJLFLN-UHFFFAOYSA-N
AS-49917
3-(Hydroxymethyl)-4-nitroaniline
O10122
AKOS016009517
Benzenemethanol, 5-amino-2-nitro-
(5-amino-2-nitro-phenyl)-methanol
3-hydroxymethyl-4-nitroaniline
5-amino-2-nitro-benzyl alcohol
5-Amino-2-nitro-benzylalkohol
AGN-PC-00LMVD
AK112537
CTK2G6534
SureCN2766494

MDL Number

MFCD00036068

FAQ

What are the physical and chemical properties of (5-Amino-2-nitrophenyl)methanol (CAS: 77376-03-5)?

(5-Amino-2-nitrophenyl)methanol is a crystalline solid with a molecular weight of approximately 210.07 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetonitrile. Chemically, it is relatively stable but can react with acids and bases. It is used as an intermediate in the synthesis of dyes and pharmaceuticals.

How is (5-Amino-2-nitrophenyl)methanol (CAS: 77376-03-5) typically synthesized?

(5-Amino-2-nitrophenyl)methanol can be synthesized by the nitration of (5-aminophenyl)methanol followed by alcoholysis. Commonly, this involves treating (5-aminophenyl)methanol with nitric acid and sulfuric acid to form the nitro compound, which is then reduced to the alcohol using a reducing agent like sodium borohydride. The overall yield is moderate, and careful control of reaction conditions is necessary.

What industries use (5-Amino-2-nitrophenyl)methanol (CAS: 77376-03-5)?

(5-Amino-2-nitrophenyl)methanol is primarily used in the pharmaceutical and dye industries. It serves as a key intermediate in the synthesis of various pharmaceutical compounds and also finds applications in the production of organic dyes due to its structural similarity to aromatic compounds.

What precautions should be taken when handling (5-Amino-2-nitrophenyl)methanol (CAS: 77376-03-5)?

Precautions for handling (5-Amino-2-nitrophenyl)methanol include wearing appropriate personal protective equipment (PPE), such as gloves and safety glasses. It should be handled in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be cleaned up using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed guidelines on handling and disposal. Proper storage should be in a cool, dry place away from direct sunlight and heat sources.