(5-Amino-2-nitrophenyl)methanol(CAS: 77376-03-5)

(5-Amino-2-nitrophenyl)methanol is a crystalline solid with a molecular weight of approximately 210.07 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetonitrile. Chemically, it is relatively stable but can react with acids and bases. It is used as an intermediate in the synthesis of dyes and pharmaceuticals.

(5-Amino-2-nitrophenyl)methanol can be synthesized by the nitration of (5-aminophenyl)methanol followed by alcoholysis. Commonly, this involves treating (5-aminophenyl)methanol with nitric acid and sulfuric acid to form the nitro compound, which is then reduced to the alcohol using a reducing agent like sodium borohydride. The overall yield is moderate, and careful control of reaction conditions is necessary.

(5-Amino-2-nitrophenyl)methanol is primarily used in the pharmaceutical and dye industries. It serves as a key intermediate in the synthesis of various pharmaceutical compounds and also finds applications in the production of organic dyes due to its structural similarity to aromatic compounds.

Precautions for handling (5-Amino-2-nitrophenyl)methanol include wearing appropriate personal protective equipment (PPE), such as gloves and safety glasses. It should be handled in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be cleaned up using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed guidelines on handling and disposal. Proper storage should be in a cool, dry place away from direct sunlight and heat sources.