Indacaterol maleate

Basic Information

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CAS Number

753498-25-8

Molecular Formula

C28H32N2O7

Molecular Weight

508.56 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CCC1=C(C=C2CC(CC2=C1)NCC(C3=C4C=CC(=O)NC4=C(C=C3)O)O)CC.C(=CC(=O)O)C(=O)O

InChI

InChI=1S/C24H28N2O3.C4H4O4/c1-3-14-9-16-11-18(12-17(16)10-15(14)4-2)25-13-22(28)19-5-7-21(27)24-20(19)6-8-23(29)26-24;5-3(6)1-2-4(7)8/h5-10,18,22,25,27-28H,3-4,11-13H2,1-2H3,(H,26,29);1-2H,(H,5,6)(H,7,8)/b;2-1-/t22-;/m0./s1

InChIKey

IREJFXIHXRZFER-PCBAQXHCSA-N

LogP

2.8607000000000014

Topological Polar Surface Area

159.94999999999996 Å²

Hydrogen Bond Donor/Acceptor

6 / 9

Complexity

708

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

INDACATEROL MALEATE [MI]
Indacaterol maleate
2(1H)-Quinolinone, 5-((1R)-2-((5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl)-8-hydroxy-, (2Z)-2-butenedioate (1:1)
HY-14299A
2(1H)-QUINOLINONE, 5-((1R)-2-((5,6-DIETHYL-2,3-DIHYDRO-1H-INDEN-2-YL)AMINO)-1-HYDROXYETHYL )-8-HYDROXY-, (2Z)-2-BUTENEDIOATE (1:1)
QAB149-AFA
753498-25-8
INDACATEROL MALEATE COMPONENT OF UTIBRON
CHEMBL1789842
Oslif Breezhaler
5-((1R)-2-((5,6-DIETHYL-2,3-DIHYDRO-1H-INDEN-2-YL)AMINO)-1-HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE HYDROGEN (2Z)-2-BUTENEDIOATE (SALT)
CCG-269764
INDACATEROL MALEATE (MART.)
S3083
Indacaterol Maleic Acid Salt
Indacaterol maleate [USAN]
Arcapta neohaler (TN)
AS-10152
5-((1R)-2-((5,6-DIETHYL-2,3-DIHYDRO-1H-INDEN-2-YL)AMINO)-1-HYDROXYETHYL)-8- HYDROXYQUINOLIN-2(1H)-ONE HYDROGEN (2Z)-2-BUTENEDIOATE (SALT)
UNII-2JEC1ITX7R
Indacaterol (as maleate)
INDACATEROL MALEATE [ORANGE BOOK]
(6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H- pyrido(3,2-b)-1,4-oxazin-4-yl)methyl dihydrogen phosphate
D09319
AC-30121
I0927
Arcapta Neohaler
753498-25-8 (malate)
Hirobriz Breezhaler
IREJFXIHXRZFER-PCBAQXHCSA-N
INDACATEROL MALEATE [EMA EPAR]

MDL Number

MFCD20526769

FAQ

What are the physical and chemical properties of Indacaterol maleate (CAS: 753498-25-8)?

Indacaterol maleate (CAS: 753498-25-8) is a crystalline compound with a molecular weight of approximately 414.5 g/mol. It has a low aqueous solubility but good solubility in organic solvents. Chemically, it is highly stable and exhibits low reactivity under normal conditions, making it suitable for pharmaceutical applications.

How is Indacaterol maleate (CAS: 753498-25-8) typically synthesized?

Indacaterol maleate is synthesized through a multi-step process involving the formation of the indacaterol intermediate followed by maleic anhydride addition. The reaction is performed under mild conditions with high selectivity, yielding a final product with a high purity grade of over 98%.

What industries use Indacaterol maleate (CAS: 753498-25-8)?

Indacaterol maleate (CAS: 753498-25-8) is primarily used in the pharmaceutical industry for the treatment of chronic obstructive pulmonary disease (COPD). It is also of interest in the research and development of new drug formulations for respiratory disorders.

What precautions should be taken when handling Indacaterol maleate (CAS: 753498-25-8)?

When handling Indacaterol maleate (CAS: 753498-25-8), proper personal protective equipment (PPE) such as gloves and safety goggles should be worn. The compound should be stored in a cool, dry place away from direct sunlight. In case of a spill, it should be cleaned up using appropriate absorbent materials and the area should be ventilated. Always consult the Safety Data Sheet (SDS) for detailed handling instructions.