1-Acetyl-5-indolinesulfonyl chloride

Basic Information

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CAS Number

52206-05-0

Molecular Formula

C10H10ClNO3S

Molecular Weight

259.71 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Solid

Melting Point

172-174 °C

SMILES

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CC(=O)N1CCC2=C1C=CC(=C2)S(=O)(=O)Cl

InChI

InChI=1S/C10H10ClNO3S/c1-7(13)12-5-4-8-6-9(16(11,14)15)2-3-10(8)12/h2-3,6H,4-5H2,1H3

InChIKey

QNFXLCHANYHGIF-UHFFFAOYSA-N

LogP

1.5231000000000001

Topological Polar Surface Area

54.45 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

389

Safety Information

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Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

QNFXLCHANYHGIF-UHFFFAOYSA-N
1-acetyl-2,3-dihydro-1H-indole-5-sulfonyl chloride
AMY25845
BB 0216554
1-acetylindoline-5-sulfonyl chloride
1-acetylindoline-5-sulphonyl chloride
FA-0854
n-acetylindoline-5-sulphonyl chloride
1-acetyl-5-indolinesulfonoyl chloride
GEO-02639
A7668
F2184-0198
J-504164
1-acetyl-2,3-dihydroindole-5-sulfonyl chloride
GS3162
A828979
1-acetyl-2,3-dihydro-1H-indole-5-sulfonyl chloride, AldrichCPR
1H-Indole-5-sulfonyl chloride, 1-acetyl-2,3-dihydro-
MFCD07368558
SCHEMBL1021359
FT-0677998
CS-0072021
DTXSID50554487
52206-05-0
EN300-15270
1-acetyl-5-indolinesulfonyl chloride
1-ethanoyl-2,3-dihydroindole-5-sulfonyl chloride
AKOS000346174
1-Acetylindoline-5-sulfonyl chloride
1-ACETYL-2,3-DIHYDRO-1H-INDOLE-5-SULFONYL CHLORIDE
1-Acetyl-5-Indolinesulfonoyl Chloride

MDL Number

MFCD07368558

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1-Acetyl-5-indolinesulfonyl chloride (CAS: 52206-05-0)?

1-Acetyl-5-indolinesulfonyl chloride (CAS: 52206-05-0) is a crystalline solid with a molecular weight of approximately 292.24 g/mol. It is poorly soluble in water but soluble in organic solvents such as acetone and methanol. The compound is highly reactive towards nucleophiles and can undergo acylation and sulfonamide formation easily.

How is 1-Acetyl-5-indolinesulfonyl chloride (CAS: 52206-05-0) typically synthesized?

1-Acetyl-5-indolinesulfonyl chloride is typically synthesized by the reaction of 5-indolinesulfonyl chloride with acetyl chloride in the presence of a base like triethylamine. The reaction yields a high percentage of the product with good selectivity and a yield of around 85-90%.

What industries use 1-Acetyl-5-indolinesulfonyl chloride (CAS: 52206-05-0)?

1-Acetyl-5-indolinesulfonyl chloride (CAS: 52206-05-0) is used primarily in the pharmaceutical industry for the synthesis of drugs. It is also utilized in the polymer industry for the preparation of functional polymers and in the semiconductor industry for the production of organic electronic materials.

What precautions should be taken when handling 1-Acetyl-5-indolinesulfonyl chloride (CAS: 52206-05-0)?

When handling 1-Acetyl-5-indolinesulfonyl chloride (CAS: 52206-05-0), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. In case of spillage, neutralize any acidic or basic materials and sweep up the residue. Always consult the Safety Data Sheet (SDS) for detailed safety information.