1-Acetyl-5-indolinesulfonyl chloride(CAS: 52206-05-0)

1-Acetyl-5-indolinesulfonyl chloride (CAS: 52206-05-0) is a crystalline solid with a molecular weight of approximately 292.24 g/mol. It is poorly soluble in water but soluble in organic solvents such as acetone and methanol. The compound is highly reactive towards nucleophiles and can undergo acylation and sulfonamide formation easily.

1-Acetyl-5-indolinesulfonyl chloride is typically synthesized by the reaction of 5-indolinesulfonyl chloride with acetyl chloride in the presence of a base like triethylamine. The reaction yields a high percentage of the product with good selectivity and a yield of around 85-90%.

1-Acetyl-5-indolinesulfonyl chloride (CAS: 52206-05-0) is used primarily in the pharmaceutical industry for the synthesis of drugs. It is also utilized in the polymer industry for the preparation of functional polymers and in the semiconductor industry for the production of organic electronic materials.

When handling 1-Acetyl-5-indolinesulfonyl chloride (CAS: 52206-05-0), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood to minimize inhalation risk. In case of spillage, neutralize any acidic or basic materials and sweep up the residue. Always consult the Safety Data Sheet (SDS) for detailed safety information.