5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol;hydrochloride | CAS No. 324077-30-7
5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol;hydrochloride
Basic Information
CAS Number
324077-30-7
Molecular Formula
C22H19ClFN3O2
Molecular Weight
411.86 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- 5-((7-BENZYLOXYQUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHENOL HYDROCHLORIDE
- ZM 323881 HCL
- ZM 323881 HYDROCHLORIDE
- ZM323881
- ZM-323881
MDL Number
MFCD05222988
FAQ
What are the physical and chemical properties of 5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride (CAS: 324077-30-7)?
5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride is a crystalline compound with a molecular weight of approximately 529.8 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and ethanol. This compound exhibits low reactivity under normal conditions but can undergo substitution reactions in the presence of appropriate reagents. Its hydrochloride salt form is commonly used in pharmaceutical applications due to its stability and solubility properties.
How is 5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride (CAS: 324077-30-7) typically synthesized?
5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride is typically synthesized through a multistep process involving the condensation of a suitable aminoquinazoline derivative with 4-fluoro-2-methylphenol. The reaction is catalyzed by a Lewis acid and proceeds with good selectivity and yield. The final product is obtained as its hydrochloride salt, which is then purified by recrystallization.
What industries use 5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride (CAS: 324077-30-7)?
5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride is primarily used in the pharmaceutical industry for the development of new drugs. It is also relevant in the chemical industry for its potential applications in sensors, semiconductors, and as a precursor in polymer synthesis. Its unique chemical structure makes it suitable for various research and development purposes.
What precautions should be taken when handling 5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride (CAS: 324077-30-7)?
When handling 5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The compound should be used in a well-ventilated area or a fume hood to minimize inhalation risks. In case of spills, immediately clean up using appropriate absorbent materials and ensure proper disposal of waste. Always refer to the Safety Data Sheet (SDS) for detailed instructions on handling and storage.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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