5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol;hydrochloride(CAS: 324077-30-7)

5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride is a crystalline compound with a molecular weight of approximately 529.8 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and ethanol. This compound exhibits low reactivity under normal conditions but can undergo substitution reactions in the presence of appropriate reagents. Its hydrochloride salt form is commonly used in pharmaceutical applications due to its stability and solubility properties.

5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride is typically synthesized through a multistep process involving the condensation of a suitable aminoquinazoline derivative with 4-fluoro-2-methylphenol. The reaction is catalyzed by a Lewis acid and proceeds with good selectivity and yield. The final product is obtained as its hydrochloride salt, which is then purified by recrystallization.

5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride is primarily used in the pharmaceutical industry for the development of new drugs. It is also relevant in the chemical industry for its potential applications in sensors, semiconductors, and as a precursor in polymer synthesis. Its unique chemical structure makes it suitable for various research and development purposes.

When handling 5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The compound should be used in a well-ventilated area or a fume hood to minimize inhalation risks. In case of spills, immediately clean up using appropriate absorbent materials and ensure proper disposal of waste. Always refer to the Safety Data Sheet (SDS) for detailed instructions on handling and storage.