Compound Q&A
How is 5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride (CAS: 324077-30-7) typically synthesized?
Answer
![5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol;hydrochloride](https://static.chemtradehub.com/structs/324/324077-30-7-dcc5.webp "5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol;hydrochloride")
5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol hydrochloride is typically synthesized through a multistep process involving the condensation of a suitable aminoquinazoline derivative with 4-fluoro-2-methylphenol. The reaction is catalyzed by a Lewis acid and proceeds with good selectivity and yield. The final product is obtained as its hydrochloride salt, which is then purified by recrystallization.
About
CAS No
324077-30-7
English Name
5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol;hydrochloride
Molecular Formula
C22H19ClFN3O2
Molecular Weight
411.86 g/mol
SMILES
Cc1cc(c(cc1O)Nc2c3ccc(cc3ncn2)OCc4ccccc4)F.Cl
InChIKey
AVRHWGLIYGJSOD-UHFFFAOYSA-N
Last Updated: 2026-01-08 21:12
![5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol;hydrochloride — Shanghai Jixiang Biotechnology Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce6f4d2b2de6e8e95a45bf/67ce6f4d2b2de6e8e95a45bf-logo.webp){kind=logo}
![5-[(7-benzyloxyquinazolin-4-yl)amino]-4-fluoro-2-methyl-phenol;hydrochloride — Jin Jinle (Hunan) Chemical Co., Ltd.](https://static.chemtradehub.com/suppliers/67ce76192b2de6e8e95a464e/67ce76192b2de6e8e95a464e-logo.webp){kind=logo}