Methyl N-Cbz-piperidine-2-carboxylate

Basic Information

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CAS Number

180609-56-7

Molecular Formula

C15H19NO4

Molecular Weight

277.31 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

390.4±42.0℃ at 760 mmHg

SMILES

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COC(=O)C1CCCCN1C(=O)OCC2=CC=CC=C2

InChI

InChI=1S/C15H19NO4/c1-19-14(17)13-9-5-6-10-16(13)15(18)20-11-12-7-3-2-4-8-12/h2-4,7-8,13H,5-6,9-11H2,1H3

InChIKey

PKYPKDMELOKLKL-UHFFFAOYSA-N

LogP

2.59030

Complexity

339

Synonyms & References

English

AM100404
SY023680
180609-56-7
Methyl 1-Cbz-piperidine-2-carboxylate
SB43166
1-benzyl 2-methyl piperidine-1,2-dicarboxylate
MFCD11111587
METHYL N-CBZ-PIPERIDINE-2-CARBOXYLATE
BENZYL 2-METHYLPIPERIDINE-1,2-DICARBOXYLATE
SCHEMBL630096
CS-0041207
R-METHYL1-CBZ-PIPERIDINE-2-CARBOXYLATE
DS-15547
FT-0771417
Piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
Piperidine-1,2-dicarboxylic acid 1-benzyl 2-methyl ester
MethylN-Cbz-piperidine-2-carboxylate
S-METHYL1-CBZ-PIPERIDINE-2-CARBOXYLATE
FT-0771331
AKOS015902133
60369-19-9
A881102
1-O-benzyl 2-O-methyl piperidine-1,2-dicarboxylate
1,2-Piperidinedicarboxylic acid, 2-methyl 1-(phenylmethyl) ester
DTXSID60451852
Methyl N-Cbz-piperidine-2-carboxylate
1,2-Piperidinedicarboxylicacid, 2-methyl 1-(phenylmethyl) ester
1-Benzyl 2-methyl piperidine-1,2-dicarboxylate
PIPERIDINE-1,2-DICARBOXYLIC ACID 1-BENZYL ESTER 2-METHYL ESTER
1-benzoxycarbonyl-2-methoxycarbonylpiperidine
FC1312

MDL Number

MFCD11111587

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Methyl N-Cbz-piperidine-2-carboxylate (CAS: 180609-56-7)?

Methyl N-Cbz-piperidine-2-carboxylate (CAS: 180609-56-7) is a crystalline solid with a molecular weight of approximately 300.35 g/mol. It has a low solubility in water but is soluble in organic solvents such as dichloromethane and acetonitrile. Chemically, it is moderately reactive towards nucleophiles and is often used as a precursors in organic synthesis. It exhibits good stability under normal storage conditions but should be handled with caution to avoid decomposition under strong acidic or basic conditions.

How is Methyl N-Cbz-piperidine-2-carboxylate (CAS: 180609-56-7) typically synthesized?

Methyl N-Cbz-piperidine-2-carboxylate (CAS: 180609-56-7) is commonly synthesized through the condensation of piperidine-2-carboxylic acid with benzyl chloroformate. The reaction is typically conducted in the presence of a base such as triethylamine. The benzyl protecting group is used to facilitate further functionalization steps in synthetic routes. This method provides good yields and high regioselectivity.

What industries use Methyl N-Cbz-piperidine-2-carboxylate (CAS: 180609-56-7)?

Methyl N-Cbz-piperidine-2-carboxylate (CAS: 180609-56-7) is primarily used in the pharmaceutical and fine chemical industries. It serves as a valuable intermediate in the synthesis of various drugs and bioactive molecules. Additionally, it is employed in the development of novel materials, such as sensors and semiconductors, due to its structural versatility and reactivity.

What precautions should be taken when handling Methyl N-Cbz-piperidine-2-carboxylate (CAS: 180609-56-7)?

When handling Methyl N-Cbz-piperidine-2-carboxylate (CAS: 180609-56-7), it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. This compound should be used in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be immediately cleaned up with appropriate absorbents. For detailed safety information, refer to the Safety Data Sheet (SDS) which provides comprehensive guidelines on handling and storage.