Fosbretabulin disodium

Basic Information

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CAS Number

168555-66-6

Molecular Formula

C18H19Na2O8P

Molecular Weight

440.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Insecticides

Basic Physical Properties

Melting Point

238-242 ºC

Boiling Point

611.8°C at 760 mmHg

Solubility

H2O: soluble5mg/mL, clear

SMILES

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COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+]

InChI

InChI=1S/C18H21O8P.2Na/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3;;/h5-11H,1-4H3,(H2,19,20,21);;/q;2*+1/p-2/b6-5-;;

InChIKey

VXNQMUVMEIGUJW-XNOMRPDFSA-L

LogP

4.23930

Complexity

496

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

CA-4P
D09346
s7204
UNII-702RHR475O
Fosbretabulin (Combretastatin A4 Phosphate,
Disodium (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl phosphate
combretastatin A4 phosphate
Phenol, 2-methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, 1-(dihydrogen phosphate), sodium salt (1:2)
C3009
Q27265817
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium
702RHR475O
Fosbretabulin disodium [USAN]
CCG-269118
PHENOL, 2-METHOXY-5-((1Z)-2-(3,4,5-TRIMETHOXYPHENYL)ETHENYL)-, DIHYDROGEN PHOSPHATE, DISODIUM SALT
2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol 1-(Dihydrogen phosphate) Sodium Salt CA 4P
Zybrestat
Fosbretabulin (disodium)
Fosbretabulin disodium (USAN)
Combretastatin A4 disodium phosphate
CA-4DP
CA 4P
Combretastatin A4 Phosphate Disodium Salt
AC-30267
Disodium(Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)phenylphosphate
SCHEMBL321426
A907765
168555-66-6
Fosbretabulin Disodium Salt
BCP9000542
disodium 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl phosphate

MDL Number

MFCD00943911

FAQ

What are the physical and chemical properties of Fosbretabulin disodium (CAS: 168555-66-6)?

Fosbretabulin disodium (CAS: 168555-66-6) is a crystalline compound with a molecular weight of approximately 576.4 g/mol. It has a solubility of about 1 mg/mL in water. This compound is relatively stable under normal conditions but may react with strong acids or bases. It is used in the pharmaceutical industry for its anti-angiogenic properties.

How is Fosbretabulin disodium (CAS: 168555-66-6) typically synthesized?

Fosbretabulin disodium is typically synthesized through a multi-step process involving the conversion of the parent compound to its sodium salt. Common methods include esterification and subsequent saponification reactions, followed by crystallization under controlled conditions. The synthesis requires careful control of reaction conditions to ensure high yield and purity.

What industries use Fosbretabulin disodium (CAS: 168555-66-6)?

Fosbretabulin disodium (CAS: 168555-66-6) is primarily used in the pharmaceutical industry, specifically for the development of anti-angiogenic drugs. It is also relevant in research and development for its potential applications in treating certain types of cancer and other vascular diseases.

What precautions should be taken when handling Fosbretabulin disodium (CAS: 168555-66-6)?

When handling Fosbretabulin disodium (CAS: 168555-66-6), wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Follow standard laboratory safety protocols, and store the compound in a cool, dry place away from strong acids and bases. Refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.