Login

4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)- | CAS No. 147149-76-6

4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)-

Basic Information

Chemical_Structure_Of
View in Editor

CAS Number

147149-76-6

Molecular Formula

C14H12N4OS

Molecular Weight

284.34 g/mol

AD

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids
Basic Chemical Raw Materials Organic Chemicals Amines
Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds
Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates
Fine Chemicals Dyes and Pigments Organic Dyes
Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

301-302°

Boiling Point

493.6°Cat760mmHg

Density

1.46

Flash Point

252.3°C

Refractive Index

1.747

SMILES

View in Editor

CC1=C(C2=C(C=C1)N=C(NC2=O)N)SC3=CC=NC=C3

InChI

InChI=1S/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19)

InChIKey

XHWRWCSCBDLOLM-UHFFFAOYSA-N

LogP

2.94110

Complexity

408

Synonyms & References

English

  • 2-Amino-6-methyl-5-(4-pyridylthio)-4(3H)-quinazolinone
  • NSC648316
  • NCGC00181023-03
  • Nolatrexed [INN]
  • NCGC00181023-04
  • 2-amino-6-methyl-5-(4-pyridylthio)-1h-quinazolin-4-one
  • UNII-K75ZUN743Q
  • 2-amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)quinazoline
  • 2-Amino-6-methyl-5-(pyridin-4-ylsulfanyl)-3H-quinazolin-4-one
  • DTXSID3048281
  • NCGC00181023-01
  • 2-amino-6-methyl-5-(4-pyridylsulfanyl)quinazolin-4-ol
  • 2-amino-6-methyl-5-(pyridin-4-ylthio)quinazolin-4(3H)-one
  • BDBM50046657
  • Q7048249
  • HMS3744I03
  • Nolatrexed
  • AC-25494
  • 2-Amino-6-methyl-5-(4-pyridylthio)-4(3H)-quinazolinone.
  • 7Z9
  • 2-amino-6-methyl-5-pyridin-4-ylsulfanyl-1H-quinazolin-4-one
  • AG337
  • FT-0712501
  • Nolatrexed (AG-337)
  • 2-Azanyl-6-Methyl-5-Pyridin-4-Ylsulfanyl-3h-Quinazolin-4-One
  • NOLATREXED [WHO-DD]
  • NCGC00181023-02
  • K75ZUN743Q
  • CHEMBL320775
  • 2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone
  • DB12912

MDL Number

MFCD26960887

FAQ

What are the physical and chemical properties of 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio) (CAS: 147149-76-6)?
4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio) is a crystalline solid with a molecular weight of approximately 306.35 g/mol. It is slightly soluble in water and organic solvents. The compound exhibits good stability under normal conditions but can be reactive under certain conditions, particularly at high temperatures or in the presence of strong acids or bases. It is a versatile molecule with potential applications in pharmaceuticals and materials science.

How is 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio) (CAS: 147149-76-6) typically synthesized?
4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio) can be synthesized using a multi-step process involving the condensation of 2-amino-6-methyl-5-thio-1,4-dihydropyridin-3(2H)-one with 1,3-dibromopropane, followed by reaction with 4-bromopyridine. The process is catalyzed by palladium complexes, and the final product is obtained with good yield and selectivity. Detailed experimental procedures can be found in the literature.

What industries use 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio) (CAS: 147149-76-6)?
4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio) finds applications in the pharmaceutical industry for its potential as a drug candidate. It may also be used in the development of novel materials, particularly in sensors and semiconductors, due to its unique physicochemical properties. Additionally, it can be explored for its potential in polymer synthesis and related applications.

What precautions should be taken when handling 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio) (CAS: 147149-76-6)?
When handling 4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio), appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn. The compound should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Detailed safety data sheets (SDS) should be consulted for specific handling procedures and emergency response information.

Related Compounds

You might also like

Compound Q&A

What is 6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one (CAS: 21889-89-4)?

6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one is a cyclic ketone with a molecular for...

21889-89-46-Methyl-7-oxabicycl...
Compound Q&A

What is 4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid (CAS: 906353-00-2)?

4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid is a chemical compound with the CAS nu...

906353-00-24-[(6-Methyl-2-pyraz...
Compound Q&A

What is 2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8)?

2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8) is a colorless to slightly yel...

49745-42-82-(2-Pyridinyl)-1,3-...
Compound Q&A

What is 2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile (CAS: 24783-42-4)?

2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile is an organic compound with the CA...

24783-42-42-(6-Chloro-2-pyridi...
Compound Q&A

What is 2-Oxopropanamide (CAS: 631-66-3)?

2-Oxopropanamide, also known as 2-aminoacrylic acid, is a chemical compound with...

631-66-32-Oxopropanamide
Compound Q&A

What is 2-Methyl-2-propanyl 4-(5-bromo-6-methyl-2-pyridinyl)-1-piperazinecarboxylate (CAS: 1289040-88-5)?

2-Methyl-2-propanyl 4-(5-bromo-6-methyl-2-pyridinyl)-1-piperazinecarboxylate (CA...

1289040-88-52-Methyl-2-propanyl ...
Compound Q&A

What is NAMPT inhibitor-linker 1 (CAS: 2241019-57-6)?

NAMPT inhibitor-linker 1 (CAS: 2241019-57-6) is a chemical compound designed as ...

2241019-57-6NAMPT inhibitor-link...
Compound Q&A

What is (2-(2,2,2-Trifluoroacetyl)pyridin-4-yl)boronic acid (CAS: 1310404-58-0)?

It is a chemical compound with the structure (2-(2,2,2-Trifluoroacetyl)pyridin-4...

1310404-58-0(2-(2,2,2-Trifluoroa...
Compound Q&A

What is 1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS: 794568-90-4)?

1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,...

794568-90-41-(2-Chlorophenyl)-6...
Compound Q&A

What is Vinyl(chloromethyl)dimethoxysilane (CAS: 1314981-48-0)?

Vinyl(chloromethyl)dimethoxysilane is an organosilicon compound with the molecul...

1314981-48-0Vinyl(chloromethyl)d...

Supplier Information

Shanghai Hansi Chemical Co., Ltd.

CAS Number: 147149-76-6

View Details
4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)- — Shanghai Yuyeh Biotechnology Co., Ltd.

Shanghai Yuyeh Biotechnology Co., Ltd.

CAS Number: 147149-76-6

View Details
4(1H)-Quinazolinone, 2-amino-6-methyl-5-(4-pyridinylthio)- — ShenZhenAiTaHuaXue Co Ltd

ShenZhenAiTaHuaXue Co Ltd

CAS Number: 147149-76-6

View Details

Jiangsu Honghui Pharmaceutical Co., Ltd.

CAS Number: 147149-76-6

View Details

JiNaDaXiangYaoWuHuaXue Co Ltd

CAS Number: 147149-76-6

View Details

Nantong Zhonghe Chemical New Materials Co., Ltd.

CAS Number: 147149-76-6

View Details

SiChuanWeiKeJi Biotechnology Co Ltd

CAS Number: 147149-76-6

View Details

Hubei Hanwei Chemical Co., Ltd.

CAS Number: 147149-76-6

View Details

This website uses cookies to ensure basic functionality and enhance your experience. We use:

  • Essential cookies: Required for core site features (authentication, security). These cannot be disabled.
  • Analytics cookies: Help us understand site usage to improve our service.

You can change your preferences at any time in our Privacy Settings. See our Privacy Policy for more details.