Azithromycin EP Impurity J

Basic Information

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CAS Number

117693-41-1

Molecular Formula

C30H58N2O9

Molecular Weight

590.8 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

137-140 ºC

SMILES

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CCC1OC(=O)C(C)C(O)C(C)C(OC2OC(C)CC(C2O)N(C)C)C(CC(CN(C(C(C1(C)O)O)C)C)C)(C)O

InChI

InChI=1S/C30H58N2O9/c1-12-22-30(8,38)25(35)20(6)32(11)15-16(2)14-29(7,37)26(18(4)23(33)19(5)27(36)40-22)41-28-24(34)21(31(9)10)13-17(3)39-28/h16-26,28,33-35,37-38H,12-15H2,1-11H3/t16-,17-,18+,19-,20-,21+,22-,23+,24-,25-,26-,28+,29-,30-/m1/s1

InChIKey

PXDYILJJHOVNLO-NZMWSZMZSA-N

LogP

0.9755000000000045

Topological Polar Surface Area

152.39 Å²

Hydrogen Bond Donor/Acceptor

5 / 11

Synonyms & References

English

Desosaminylazithromycin
Descladinose Azithromycin
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10,13-tetrahydro xy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadecan -11-yl 3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranoside
DECLADINOSYLAZITHROMYCIN
3-decladinosyl azithromycin
3-Octyn-1-ol
3-octyne-1-ol
3-O-decladinosyl-9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A
3-O-decladinosyl-azithromycin
3-O-descladinosylazithromycin
5-O-desosaminyl-9-deoxo-9a-aza-9a-methyl-9a-homoerythronolide A
descladinose
descladinosyl azithromycin
Oct-3-in-1-ol
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10,13-tetrahydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
CP 66458
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10,13-tetrahydroxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one

MDL Number

MFCD22572720

FAQ

What are the physical and chemical properties of Azithromycin EP Impurity J (CAS: 117693-41-1)?

Azithromycin EP Impurity J (CAS: 117693-41-1) is a derivative of azithromycin, a macrolide antibiotic. It has a molecular weight of approximately 966.91 g/mol. This impurity is poorly soluble in water but has better solubility in organic solvents like methanol. It is slightly reactive with bases, showing some tendency to form complexes, but it does not participate in typical acid-base reactions under normal conditions. The crystalline form of this impurity is stable under normal laboratory conditions.

How is Azithromycin EP Impurity J (CAS: 117693-41-1) typically synthesized?

Azithromycin EP Impurity J (CAS: 117693-41-1) is typically synthesized as a side product during the production of azithromycin. The synthesis involves a series of reactions including acetylation, oxidation, and reduction steps. Commonly used catalysts include organic acids and metal complexes. The overall yield is around 5-10%, and the process requires careful control of pH and temperature to ensure high selectivity and purity.

What industries use Azithromycin EP Impurity J (CAS: 117693-41-1)?

Azithromycin EP Impurity J (CAS: 117693-41-1) is primarily used in the pharmaceutical industry, specifically in the production of azithromycin derivatives. It is also of interest to researchers studying antibiotic impurities and their effects on drug efficacy and safety. While it does not have direct applications in industries like polymers, sensors, or semiconductors, its study contributes to the broader field of drug development and quality control.

What precautions should be taken when handling Azithromycin EP Impurity J (CAS: 117693-41-1)?

When handling Azithromycin EP Impurity J (CAS: 117693-41-1), it is important to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or under a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents. Always refer to the safety data sheet (SDS) for detailed guidelines on storage, disposal, and handling of this compound. Proper training in chemical handling is essential to ensure safety in the laboratory.