5-fluoro-3-nitro-pyridin-2-ol

Basic Information

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CAS Number

136888-20-5

Molecular Formula

C5H3FN2O3

Molecular Weight

158.09 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Boiling Point

314.6°C at 760 mmHg

Density

1.55

Water Solubility

Slightly soluble in water.

Flash Point

104.5℃

Refractive Index

1.59

SMILES

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C1=C(C(=O)NC=C1F)[N+](=O)[O-]

InChI

InChI=1S/C5H3FN2O3/c6-3-1-4(8(10)11)5(9)7-2-3/h1-2H,(H,7,9)

InChIKey

BLFUHTOZIOQGBU-UHFFFAOYSA-N

LogP

1.35770

Complexity

276

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

FT-0648950
5-fluro-2-hydroxy-3-nitropyridine
DTXSID60441990
CS-W022382
Q-103396
SB52354
5-fluoro-3-nitro-pyridin-2-ol
5-Fluoro-3-nitro-2-pyridinol
2(1H)-PYRIDINONE, 5-FLUORO-3-NITRO-
5-fluoro-3-nitro-1H-pyridin-2-one
AC-23697
5-FLUORO-2-HYDROXY-3-NITROPYRPUBCHEM_EXT_DATASOURCE_REGIDINE
BP-11917
DS-0716
AKOS005063782
AM20050802
136888-20-5
GS-5023
5-fluoranyl-3-nitro-1H-pyridin-2-one
A26042
AKOS015833758
5-Fluoro-3-nitropyridin-2(1H)-one
SY011628
BLFUHTOZIOQGBU-UHFFFAOYSA-N
5-fluoro-2-hydroxy-3-nitropyridine
MFCD05662412
SCHEMBL845293
2-hydroxy-3-nitro-5-fluoropyridine;2-hydroxy-5-fluoro-3-nitropyridine;5-bromo-2-methoxynicotinaldehyde;5-fluoro-3-nitropyridin-2-ol;5-fluoro-2-hydroxy-3-nitrop;5-Fluoro-3-nitropyridin-2(1H)-one
5-Fluoro-3-nitropyridin-2(1H)-one pound>>2-Hydroxy-3-nitro-5-fluoropyridine
5-fluoro-3-nitropyridin-2-ol
EN300-106917

MDL Number

MFCD05662412

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 5-fluoro-3-nitro-pyridin-2-ol (CAS: 136888-20-5)?

5-fluoro-3-nitro-pyridin-2-ol (CAS: 136888-20-5) is a crystalline solid with a molecular weight of approximately 213.07 g/mol. It has a low solubility in water and is more soluble in organic solvents like ethanol and acetone. Chemically, it is highly reactive due to the presence of the nitro and fluoro substituents, making it useful in various chemical transformations and reactions.

How is 5-fluoro-3-nitro-pyridin-2-ol (CAS: 136888-20-5) typically synthesized?

5-fluoro-3-nitro-pyridin-2-ol (CAS: 136888-20-5) can be synthesized through the reduction of 5-nitro-3-pyridon-2-ol followed by fluorination. Common methods include using sodium borohydride for reduction and various fluorinating agents like hydrogen fluoride or fluorine gas for the fluorination step. The reaction conditions are typically optimized for high yield and selectivity.

What industries use 5-fluoro-3-nitro-pyridin-2-ol (CAS: 136888-20-5)?

5-fluoro-3-nitro-pyridin-2-ol (CAS: 136888-20-5) finds applications in pharmaceuticals and organic synthesis, particularly in the development of novel drugs and intermediates. It is also used in the preparation of certain dyes and as a reagent in academic and industrial laboratories.

What precautions should be taken when handling 5-fluoro-3-nitro-pyridin-2-ol (CAS: 136888-20-5)?

5-fluoro-3-nitro-pyridin-2-ol (CAS: 136888-20-5) requires careful handling due to its reactivity. Always wear appropriate personal protective equipment (PPE), including gloves and goggles. Work should be performed in a well-ventilated fume hood. In case of a spill, immediately clean up using appropriate absorbent materials and follow the Material Safety Data Sheet (MSDS) for further guidance. Proper disposal must be carried out in accordance with local regulations.