5-fluoro-3-nitro-pyridin-2-ol(CAS: 136888-20-5)

5-fluoro-3-nitro-pyridin-2-ol (CAS: 136888-20-5) is a crystalline solid with a molecular weight of approximately 213.07 g/mol. It has a low solubility in water and is more soluble in organic solvents like ethanol and acetone. Chemically, it is highly reactive due to the presence of the nitro and fluoro substituents, making it useful in various chemical transformations and reactions.

5-fluoro-3-nitro-pyridin-2-ol (CAS: 136888-20-5) can be synthesized through the reduction of 5-nitro-3-pyridon-2-ol followed by fluorination. Common methods include using sodium borohydride for reduction and various fluorinating agents like hydrogen fluoride or fluorine gas for the fluorination step. The reaction conditions are typically optimized for high yield and selectivity.

5-fluoro-3-nitro-pyridin-2-ol (CAS: 136888-20-5) finds applications in pharmaceuticals and organic synthesis, particularly in the development of novel drugs and intermediates. It is also used in the preparation of certain dyes and as a reagent in academic and industrial laboratories.

5-fluoro-3-nitro-pyridin-2-ol (CAS: 136888-20-5) requires careful handling due to its reactivity. Always wear appropriate personal protective equipment (PPE), including gloves and goggles. Work should be performed in a well-ventilated fume hood. In case of a spill, immediately clean up using appropriate absorbent materials and follow the Material Safety Data Sheet (MSDS) for further guidance. Proper disposal must be carried out in accordance with local regulations.