2-Amino-5-methoxybenzenesulfonic acid

Basic Information

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CAS Number

13244-33-2

Molecular Formula

C7H9NO4S

Molecular Weight

203.22 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

314-318 C

Boiling Point

°Cat760mmHg

Refractive Index

1.6370 (estimate)

SMILES

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COC1=CC(=C(C=C1)N)S(=O)(=O)O

InChI

InChI=1S/C7H9NO4S/c1-12-5-2-3-6(8)7(4-5)13(9,10)11/h2-4H,8H2,1H3,(H,9,10,11)

InChIKey

KZKGEEGADAWJFS-UHFFFAOYSA-N

LogP

0.5241

Topological Polar Surface Area

89.62 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

258

Synonyms & References

English

2-Amino-5-methoxybenzenesulfonicacid
0-14-00-00813 (Beilstein Handbook Reference)
4-Methoxy-2-sulfoaniline
BRN 3284409
UNII-HJU535J932
Kyselina 4-aminoanisol-3-sulfonova [Czech]
DTXSID2065381
A1285
SY052063
EINECS 236-224-2
2-amino-5-methoxybenzene-1-sulfonic acid
BS-23820
Z1269122561
4-anisidine-2-sulfonicacid
1-amino-4-methoxybenzene-2-sulphonic acid
EN300-123857
2-Amino-5-methoxybenzenesulphonic acid
D85920
MFCD00035804
AKOS015960523
AC-11599
p-Anisidine-3-sulfonicAcid
4-anisidine-2-sulfonic acid
2-amino-5-methoxy-benzenesulfonate
KZKGEEGADAWJFS-UHFFFAOYSA-N
FT-0611176
2-Amino-5-methoxybenzene sulfonic acid
Kyselina 4-aminoanisol-3-sulfonova
SCHEMBL158764
4-Methoxyaniline-2-sulfonic Acid
4-Aminoanisole-3-sulfonic acid

MDL Number

MFCD00035804

Customs Code

2922299090

FAQ

What are the physical and chemical properties of 2-Amino-5-methoxybenzenesulfonic acid (CAS: 13244-33-2)?

2-Amino-5-methoxybenzenesulfonic acid (CAS: 13244-33-2) is a white crystalline solid with a molecular weight of approximately 234.22 g/mol. It has a solubility of about 20 g/L in water at 25°C. It is moderately reactive, especially in acidic conditions, and can undergo substitution reactions and coupling reactions. It is slightly soluble in common organic solvents like ethanol and acetone.

How is 2-Amino-5-methoxybenzenesulfonic acid (CAS: 13244-33-2) typically synthesized?

2-Amino-5-methoxybenzenesulfonic acid is typically synthesized via the sulfonation of 5-methoxy-anisidine followed by sulfonation. Common methods involve the use of fuming sulfuric acid or oleum as the sulfonating agent. The reaction is carried out under controlled temperature conditions to achieve high selectivity and yield.

What industries use 2-Amino-5-methoxybenzenesulfonic acid (CAS: 13244-33-2)?

2-Amino-5-methoxybenzenesulfonic acid is used in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of certain drugs. It is also used in the production of dyes and pigments, as a reagent in analytical chemistry, and in the development of sensors and semiconductors.

What precautions should be taken when handling 2-Amino-5-methoxybenzenesulfonic acid (CAS: 13244-33-2)?

Handling 2-Amino-5-methoxybenzenesulfonic acid requires caution due to its potential for skin irritation and respiratory sensitization. Adequate Personal Protective Equipment (PPE) such as gloves, goggles, and protective clothing should be worn. Work should be conducted in a fume hood to minimize exposure. Spills should be handled with appropriate absorbents, and the material safety data sheet (SDS) should be consulted for detailed spill cleanup procedures.