2-Amino-5-methoxybenzenesulfonic acid(CAS: 13244-33-2)

2-Amino-5-methoxybenzenesulfonic acid (CAS: 13244-33-2) is a white crystalline solid with a molecular weight of approximately 234.22 g/mol. It has a solubility of about 20 g/L in water at 25°C. It is moderately reactive, especially in acidic conditions, and can undergo substitution reactions and coupling reactions. It is slightly soluble in common organic solvents like ethanol and acetone.

2-Amino-5-methoxybenzenesulfonic acid is typically synthesized via the sulfonation of 5-methoxy-anisidine followed by sulfonation. Common methods involve the use of fuming sulfuric acid or oleum as the sulfonating agent. The reaction is carried out under controlled temperature conditions to achieve high selectivity and yield.

2-Amino-5-methoxybenzenesulfonic acid is used in various industries, including pharmaceuticals, where it serves as an intermediate in the synthesis of certain drugs. It is also used in the production of dyes and pigments, as a reagent in analytical chemistry, and in the development of sensors and semiconductors.

Handling 2-Amino-5-methoxybenzenesulfonic acid requires caution due to its potential for skin irritation and respiratory sensitization. Adequate Personal Protective Equipment (PPE) such as gloves, goggles, and protective clothing should be worn. Work should be conducted in a fume hood to minimize exposure. Spills should be handled with appropriate absorbents, and the material safety data sheet (SDS) should be consulted for detailed spill cleanup procedures.