1-(Tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid | CAS No. 1303974-46-0
1-(Tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid
Basic Information
CAS Number
1303974-46-0
Molecular Formula
C11H18FNO4
Molecular Weight
247.27 g/mol
AD
Chemical Classification
Basic Physical Properties
Safety Information
View Safety InformationHazard Statement
H302
Harmful if swallowed
Acute toxicity, oral
Acute toxicity, oral
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Synonyms & References
English
- 1-(tert-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid
- 3-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic acid
- 1-[(tert-butoxy)carbonyl]-3-fluoropiperidine-4-carboxylic acid
- rel-(3S,4S)-1-(tert-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid
- VAXFBQGBIHPZCF-UHFFFAOYSA-N
- trans-1-(tert-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid
- 3-fluoro-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester
- PB41591
- SY248511
- EN300-1716118
- (3S,4R)-1-Boc-3-fluoropiperidine-4-carboxylic Acid
- AB87601
- AM807666
- (3s,4s)-1-Tert-butoxycarbonyl-3-fluoro-piperidine-4-carboxylicacid
- 1-Boc-3-fluoropiperidine-4-carboxylic acid
- (3,4)-Cis-1-(tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid racemate
- 1-(t-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid
- CS-W001393
- A910459
- 1932149-31-9
- AKOS022178213
- (3,4)-Trans-1-(tert-butoxycarbonyl)-3-fluoropiperi dine-4-carboxylic acid racemate
- SCHEMBL16057759
- AS-54518
- (3R,4S)-1-Boc-3-fluoropiperidine-4-carboxylic Acid
- 1903422-62-7
- SB23166
- 1-(tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylicacid
- (3,4)-Trans-1-(tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid
- SY109082
- s11171
MDL Number
MFCD18909772
FAQ
What are the physical and chemical properties of 1-(Tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid (CAS: 1303974-46-0)?
1-(Tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid is a colorless crystalline solid with a molecular weight of approximately 276.38 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMSO and methanol. Chemically, it is highly reactive due to the presence of the carboxylic acid group and the fluorine substituent. It is prone to esterification and amidation reactions.
How is 1-(Tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid (CAS: 1303974-46-0) typically synthesized?
1-(Tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid is typically synthesized through a multi-step process involving the formation of a piperidine ring, followed by protection of the amine with tert-butoxycarbonyl (Boc) group, and subsequent introduction of the fluorine substituent. Commonly, this involves reactions like debenzylation, N-protectylation, and fluorination, with high selectivity and yield.
What industries use 1-(Tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid (CAS: 1303974-46-0)?
1-(Tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid is primarily used in the pharmaceutical industry for the synthesis of complex molecules and bioactive compounds. It may also find applications in polymer chemistry for developing novel materials and in the development of sensors and semiconductors due to its unique chemical properties.
What precautions should be taken when handling 1-(Tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid (CAS: 1303974-46-0)?
When handling 1-(Tert-butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation of vapors. Spills should be immediately cleaned up using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and storage instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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