γ-Cyclodextrin, 2-hydroxypropyl ethers

Basic Information

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CAS Number

128446-34-4

Molecular Formula

C63H110O45

Molecular Weight

1587.53 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

52-55 °C

Boiling Point

97-98 °C3 mm Hg

Flash Point

>230 °F

Solubility

H2O: soluble450mg/mL

SMILES

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CC(COCC1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(C(C8O)O)OC9C(OC(O2)C(C9O)O)CO)CO)COCC(C)O)COCC(C)O)CO)COCC(C)O)COCC(C)O)O)O)O

InChI

InChI=1S/C63H110O45/c1-19(67)9-88-14-27-51-38(78)46(86)62(99-27)108-55-31(18-92-13-23(5)71)100-63(47(87)39(55)79)107-54-30(17-91-12-22(4)70)97-60(44(84)36(54)76)103-50-26(8-66)95-58(42(82)34(50)74)105-52-28(15-89-10-20(2)68)98-61(45(85)37(52)77)106-53-29(16-90-11-21(3)69)96-59(43(83)35(53)75)102-49-25(7-65)93-56(40(80)32(49)72)101-48-24(6-64)94-57(104-51)41(81)33(48)73/h19-87H,6-18H2,1-5H3

InChIKey

SYRUEUHBRJCPED-UHFFFAOYSA-N

LogP

-15.380899999999967

Topological Polar Surface Area

679.3500000000004 Å²

Hydrogen Bond Donor/Acceptor

24 / 45

Complexity

157

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

g-Cyclodextrin, 2-hydroxypropylethers
(2-Hydroxypropyl)-γ-cyclodextrin
(2-Hydroxypropyl)-β-cyclodextrin
2-fluoro-4-methyl-1-nitrobenzene
3-Fluoro-4-nitrotoluene
2-fluor-4-methyl-1-nitrobenzol
2-Fluoro-4-methylnitrobenzene
2-Hydroxyphenylacetic Acid
3-fluoro-4-nitrobenzene
AG-D-58639
Benzene, 2-fluoro-4-methyl-1-nitro-
SBB063399
Cavasol® W8 HP
HGC
CAVASOL(R)W8
Cavasol? W8 HP
(2-Hydroxypropyl)-γ-cyclodextrin,HGC
(2-Hydroxypropyl)-gamma-cyclodextrinsolid
.gamma.-Cyclodextrin, 2-hydroxypropyl ethers
(2-Hydroxypropyl)-gaMMa-cyclodextrin extent of labeling: 0.6 Molar substitution
V SOLUTION IN H2O
(2-Hydroxypropyl)-γ-cyclodextrin,average Mw ~1,580
Hydroxypropyl-γ-cyclodextrin
WZMOWQCNPFDWPA-UHFFFAOYSA-N
2-fluoro-4-methyl-1-nitro-benzene
NSC25756
PubChem1595
3-fluoro4-nitrotoluene
3-fluoro-4-nitro-toluene
3-fluoro-4-nitro toluene
2-Amino-5-fluorobenzoicacid

MDL Number

MFCD00148890

FAQ

What are the physical and chemical properties of γ-Cyclodextrin, 2-hydroxypropyl ethers (CAS: 128446-34-4)?

γ-Cyclodextrin, 2-hydroxypropyl ethers (CAS: 128446-34-4) is a white to off-white crystalline powder. It has a molecular weight of approximately 1560 g/mol and is poorly soluble in water. It exhibits moderate solubility in organic solvents such as ethanol and acetone. This compound is known for its ability to form inclusion complexes with various guest molecules, making it highly reactive in certain chemical transformations.

How is γ-Cyclodextrin, 2-hydroxypropyl ethers (CAS: 128446-34-4) typically synthesized?

γ-Cyclodextrin, 2-hydroxypropyl ethers (CAS: 128446-34-4) is typically synthesized by the reaction of γ-cyclodextrin with epichlorohydrin in the presence of a strong base such as sodium hydroxide. The process involves a nucleophilic substitution reaction, leading to the formation of ethers. The yield is generally around 70-80%, and the reaction is highly selective, producing a pure product.

What industries use γ-Cyclodextrin, 2-hydroxypropyl ethers (CAS: 128446-34-4)?

γ-Cyclodextrin, 2-hydroxypropyl ethers (CAS: 128446-34-4) is widely used in the pharmaceutical industry for drug delivery systems, improving the solubility and stability of drugs. It is also utilized in the food industry for stabilizing and emulsifying food products. Additionally, it finds applications in the sensor technology for detecting specific analytes, and in the semiconductor industry for improving the performance of certain electronic components.

What precautions should be taken when handling γ-Cyclodextrin, 2-hydroxypropyl ethers (CAS: 128446-34-4)?

When handling γ-Cyclodextrin, 2-hydroxypropyl ethers (CAS: 128446-34-4), it is essential to use appropriate personal protective equipment (PPE), including gloves and safety goggles. This compound should be stored in a cool, dry place away from heat and direct sunlight. In case of spills, they should be cleaned up using appropriate methods, and the area should be ventilated. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures.