4-Chloro-3-methoxy-2-methylpyridine 1-oxide

Basic Information

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CAS Number

122307-41-9

Molecular Formula

C7H8ClNO2

Molecular Weight

173.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

98.0 to 102.0 deg-C

SMILES

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CC1=[N+](C=CC(=C1OC)Cl)[O-]

InChI

InChI=1S/C7H8ClNO2/c1-5-7(11-2)6(8)3-4-9(5)10/h3-4H,1-2H3

InChIKey

TWXMQDRFBLSXFN-UHFFFAOYSA-N

LogP

2.08550

Complexity

134

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

4-Chloro-3-methoxy-2-methylpyridine1-oxide
A804870
4-chloro-3-methoxy-2-methyl-1-oxidopyridin-1-ium
EC 602-491-2
AC-8440
NS00004558
122307-41-9
Pyridine, 4-chloro-3-methoxy-2-methyl-, 1-oxide
AKOS015891516
4-Chloro-3-methoxy-2-methylpyridine N-oxide
SY018469
FT-0642982
Q-200452
AMY37202
MFCD03093995
SCHEMBL317432
4-Chloro-2-methyl-3-methoxypyridine N-oxide; 4-Chloro-3-methoxy-2-methylpyridine N-oxide
2-methyl-3-methoxy-4-chloropyridine N-oxide
AS-10872
4-Chloro-2-methyl-3-methoxypyridine N-Oxide
C2402
4-Chloro-3-methoxy-2-methylpyridine N-oxide, 97%
4-Chloro-3-methoxy-2-methylpyridine 1-oxide
F12227
ZB1366
TWXMQDRFBLSXFN-UHFFFAOYSA-N
DTXSID10408154
4-Chloro-3-Methoxy-2-Methylpyridine N-Oxide
2-Methyl-3-methoxy-4-chloropyridineN-oxide
4-Chloro-2-methyl-3-methoxypyridine N-oxide
Intermediate of pantoprazole sodium

MDL Number

MFCD03093995

FAQ

What are the physical and chemical properties of 4-Chloro-3-methoxy-2-methylpyridine 1-oxide (CAS: 122307-41-9)?

4-Chloro-3-methoxy-2-methylpyridine 1-oxide (CAS: 122307-41-9) is a crystalline solid with a molecular weight of approximately 208.02 g/mol. It has a melting point of about 113-115°C and is slightly soluble in water. This compound is known for its reactivity towards nucleophiles and electrophiles, making it useful in organic synthesis. It can form stable solutions in organic solvents like ethanol and acetone.

How is 4-Chloro-3-methoxy-2-methylpyridine 1-oxide (CAS: 122307-41-9) typically synthesized?

4-Chloro-3-methoxy-2-methylpyridine 1-oxide (CAS: 122307-41-9) is typically synthesized through the methylation of 4-chloro-3-methoxy-2-pyridinecarbaldehyde followed by oxidation. This involves the use of methyl iodide and a strong base, such as sodium hydride, in an organic solvent. The reaction is conducted at room temperature, and the final product is obtained by oxidizing the intermediate with potassium permanganate or a similar oxidizing agent.

What industries use 4-Chloro-3-methoxy-2-methylpyridine 1-oxide (CAS: 122307-41-9)?

4-Chloro-3-methoxy-2-methylpyridine 1-oxide (CAS: 122307-41-9) is primarily used in the pharmaceutical, pesticide, and fine chemical industries. It serves as a precursor for the synthesis of various drugs and agrochemicals. Its application in the pharmaceutical industry includes the production of APIs (active pharmaceutical ingredients) and intermediates for drug synthesis. It is also utilized in the development of new pesticides and herbicides.

What precautions should be taken when handling 4-Chloro-3-methoxy-2-methylpyridine 1-oxide (CAS: 122307-41-9)?

When handling 4-Chloro-3-methoxy-2-methylpyridine 1-oxide (CAS: 122307-41-9), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be stored in a cool, well-ventilated area away from heat sources, as it is sensitive to moisture and may decompose. Handling should be done in a fume hood to minimize exposure to vapors. In case of spill, avoid inhalation and contact with skin or eyes. Consult the Safety Data Sheet (SDS) for detailed emergency procedures.