4-Chloro-3-methoxy-2-methylpyridine 1-oxide(CAS: 122307-41-9)

4-Chloro-3-methoxy-2-methylpyridine 1-oxide (CAS: 122307-41-9) is a crystalline solid with a molecular weight of approximately 208.02 g/mol. It has a melting point of about 113-115°C and is slightly soluble in water. This compound is known for its reactivity towards nucleophiles and electrophiles, making it useful in organic synthesis. It can form stable solutions in organic solvents like ethanol and acetone.

4-Chloro-3-methoxy-2-methylpyridine 1-oxide (CAS: 122307-41-9) is typically synthesized through the methylation of 4-chloro-3-methoxy-2-pyridinecarbaldehyde followed by oxidation. This involves the use of methyl iodide and a strong base, such as sodium hydride, in an organic solvent. The reaction is conducted at room temperature, and the final product is obtained by oxidizing the intermediate with potassium permanganate or a similar oxidizing agent.

4-Chloro-3-methoxy-2-methylpyridine 1-oxide (CAS: 122307-41-9) is primarily used in the pharmaceutical, pesticide, and fine chemical industries. It serves as a precursor for the synthesis of various drugs and agrochemicals. Its application in the pharmaceutical industry includes the production of APIs (active pharmaceutical ingredients) and intermediates for drug synthesis. It is also utilized in the development of new pesticides and herbicides.

When handling 4-Chloro-3-methoxy-2-methylpyridine 1-oxide (CAS: 122307-41-9), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be stored in a cool, well-ventilated area away from heat sources, as it is sensitive to moisture and may decompose. Handling should be done in a fume hood to minimize exposure to vapors. In case of spill, avoid inhalation and contact with skin or eyes. Consult the Safety Data Sheet (SDS) for detailed emergency procedures.