R-(-)-Clopidogrel Hydrogen Sulfate

Basic Information

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CAS Number

120202-71-3

Molecular Formula

C16H18ClNO6S2

Molecular Weight

419.91 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

47-49°C

Boiling Point

423.7°C at 760 mmHg

Flash Point

210°C

Solubility

Methanol (Slightly)

SMILES

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COC(=O)[C@H](N1CCc2sccc2C1)c3ccccc3Cl.OS(=O)(=O)O

InChI

InChI=1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)/t15-;/m1./s1

InChIKey

FDEODCTUSIWGLK-XFULWGLBSA-N

LogP

3.0211000000000006

Topological Polar Surface Area

104.14 Å²

Hydrogen Bond Donor/Acceptor

2 / 7

Complexity

463

Safety Information

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Stability

Very Hygroscopic

Synonyms & References

English

(R)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate
R-(-)-Clopidogrel Hydrogen Sulfate
CLOPIDOGREL BISULFATE IMPURITY C
Clopidogrel Related Compound C
Methyl (-)-(R)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate, hydrogen sulfate
methyl (2R)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate,sulfuric acid
(R)-Clopidogrel bisulfate
(R)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate hydrogensulfate
(R)-(-)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate hydrogen sulfate
(R)-(-)-Methyl (2-chlorophenyl)(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetate bisulfate
SR 25989C
acetate sulfate
Clopidogrel Rel Cpd C
Clopidogrel Impurity C
Clopidogrel Impurity III
Clopidogrel EP IMpurity-C
Clopidogrel EP impurity-C (USP RC C)
AK114294
5(4H)-yl)acetate sulfate
(R)-Clopidogrel Hydrogen Sulfate
Clopidogrel USP Related CoMpound C
methyl (2R)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate;sulfuric acid
BCP09706
(6,7-dihydrothieno[3,2-c]pyridin-
(R)-Methyl 2-(2-chlorophenyl)-2-
BC658549
ST2402675
AX8221120
methyl (2R
Clopidogrel Related CoMpound C
methyl (R)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate

MDL Number

MFCD17215518

Customs Code

2934999090

FAQ

What are the physical and chemical properties of R-(-)-Clopidogrel Hydrogen Sulfate (CAS: 120202-71-3)?

R-(-)-Clopidogrel Hydrogen Sulfate is a crystalline compound with a molecular weight of approximately 340.36 g/mol. It is sparingly soluble in water and alcohol but readily soluble in dilute acid. The compound is less reactive than its parent compound, clopidogrel, and is used primarily in pharmaceutical applications.

How is R-(-)-Clopidogrel Hydrogen Sulfate (CAS: 120202-71-3) typically synthesized?

R-(-)-Clopidogrel Hydrogen Sulfate is synthesized by the stereoselective hydrogenation of clopidogrel using a chiral ligand with a palladium catalyst. The process yields a stereoisomerically pure product with high selectivity, typically achieving an enantiomeric excess greater than 99%. The synthesis involves multiple steps requiring controlled temperature and pressure conditions.

What industries use R-(-)-Clopidogrel Hydrogen Sulfate (CAS: 120202-71-3)?

R-(-)-Clopidogrel Hydrogen Sulfate is primarily used in the pharmaceutical industry. It is an active pharmaceutical ingredient (API) used in the formulation of antiplatelet medications, such as Plavix, to prevent thrombosis. It is not commonly used in other industries like polymers, sensors, or semiconductors.

What precautions should be taken when handling R-(-)-Clopidogrel Hydrogen Sulfate (CAS: 120202-71-3)?

Handling R-(-)-Clopidogrel Hydrogen Sulfate should be done in a ventilated area, such as a fume hood, to minimize inhalation risks. Personal protective equipment (PPE) including gloves, safety glasses, and a lab coat is recommended. Spills should be cleaned up immediately using appropriate absorbents, and the area should be thoroughly washed. A safety data sheet (SDS) should be consulted before handling the compound.