R-(-)-Clopidogrel Hydrogen Sulfate(CAS: 120202-71-3)

R-(-)-Clopidogrel Hydrogen Sulfate is a crystalline compound with a molecular weight of approximately 340.36 g/mol. It is sparingly soluble in water and alcohol but readily soluble in dilute acid. The compound is less reactive than its parent compound, clopidogrel, and is used primarily in pharmaceutical applications.

R-(-)-Clopidogrel Hydrogen Sulfate is synthesized by the stereoselective hydrogenation of clopidogrel using a chiral ligand with a palladium catalyst. The process yields a stereoisomerically pure product with high selectivity, typically achieving an enantiomeric excess greater than 99%. The synthesis involves multiple steps requiring controlled temperature and pressure conditions.

R-(-)-Clopidogrel Hydrogen Sulfate is primarily used in the pharmaceutical industry. It is an active pharmaceutical ingredient (API) used in the formulation of antiplatelet medications, such as Plavix, to prevent thrombosis. It is not commonly used in other industries like polymers, sensors, or semiconductors.

Handling R-(-)-Clopidogrel Hydrogen Sulfate should be done in a ventilated area, such as a fume hood, to minimize inhalation risks. Personal protective equipment (PPE) including gloves, safety glasses, and a lab coat is recommended. Spills should be cleaned up immediately using appropriate absorbents, and the area should be thoroughly washed. A safety data sheet (SDS) should be consulted before handling the compound.