Avibactam sodium

Basic Information

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CAS Number

1192491-61-4

Molecular Formula

C7H10N3NaO6S

Molecular Weight

287.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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C1CC(N2CC1N(C2=O)OS(=O)(=O)[O-])C(=O)N.[Na+]

InChI

1S/C7H11N3O6S.Na/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15;/h4-5H,1-3H2,(H2,8,11)(H,13,14,15);/q;+1/p-1/t4-,5+;/m1./s1

InChIKey

RTCIKUMODPANKX-JBUOLDKXSA-M

LogP

0.45350

Complexity

462

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Avibactam Sodium Salt
Avibactam sodium
NXL 104
NXL-104
sodium,[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] sulfate
(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide monosodium salt
Avibactam (sodium)
9V824P8TAI
NXL104
Avibactam sodium [USAN]
avibactam-sodium
Sulfuric acid, mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester, sodium salt (1:1)
Sulfuric acid, mono((1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo(3.2.1)oct-6-yl) ester, sodium salt (1:1)
sodium (1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
Sodium (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
sodium;[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] sulfate
Sulfuric acid, mono((1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo(3.2.1)oct
(1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
sodium salt (1:1)
GLXC-04187
Avibactam Sodium Isomer
AVE-1330A
AKOS030243377
SCHEMBL14247700
Q27158832
US9035062, 23
BDBM50512951
HY-14879A
AC-29295
CHEBI:85982
sodium avibactam(1-)

MDL Number

MFCD29472268

FAQ

What is Avibactam sodium (CAS: 1192491-61-4)?

Avibactam sodium (CAS: 1192491-61-4) is a beta-lactamase inhibitor used in combination with beta-lactam antibiotics to combat drug-resistant bacterial infections. Its chemical formula is C18H23N5O6S2, and it exhibits stability in aqueous solutions. Avibactam sodium is characterized by its ability to enhance the efficacy of antibiotics by preventing bacterial enzymes from degrading them, making it a critical component in modern antimicrobial therapies.

What are the main uses of Avibactam sodium (CAS: 1192491-61-4)?

Avibactam sodium (CAS: 1192491-61-4) is primarily used in pharmaceuticals as a synergistic agent with antibiotics like ceftazidime and cefepime. It targets Gram-negative bacteria resistant to beta-lactam antibiotics, aiding in treating severe infections such as pneumonia and urinary tract infections. Additionally, it plays a role in research for developing new antimicrobial strategies against drug-resistant pathogens.

Is Avibactam sodium (CAS: 1192491-61-4) safe?

Avibactam sodium (CAS: 1192491-61-4) is considered safe when used as directed in medical treatments. However, it requires proper handling to avoid potential irritation or allergic reactions. Safety standards, including ICH guidelines, emphasize protective measures like gloves and eye protection during preparation. It is not intended for direct consumer use and should be handled by trained professionals.

How should Avibactam sodium (CAS: 1192491-61-4) be stored?

Avibactam sodium (CAS: 1192491-61-4) should be stored at controlled room temperature (2-8°C) in a dry, light-protected environment. It is typically kept in sealed, airtight containers to maintain stability and prevent degradation. Avoid exposure to moisture, direct sunlight, and extreme temperatures to ensure optimal shelf life and efficacy.