Bleomycin A5 | CAS No. 11116-32-8

Bleomycin A5

Basic Information

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CAS Number

11116-32-8

Molecular Formula

C57H89N19O21S2

Molecular Weight

1440.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Refractive Index

1.6700 (estimate)

SMILES

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CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCCNCCCCN)O

InChI

InChI=1S/C57H89N19O21S2/c1-22-35(73-48(76-46(22)61)27(14-33(60)80)68-15-26(59)47(62)86)52(90)75-37(43(28-16-65-21-69-28)95-56-45(41(84)39(82)31(17-77)94-56)96-55-42(85)44(97-57(63)92)40(83)32(18-78)93-55)53(91)70-24(3)38(81)23(2)49(87)74-36(25(4)79)51(89)67-13-8-34-71-30(20-98-34)54-72-29(19-99-54)50(88)66-12-7-11-64-10-6-5-9-58/h16,19-21,23-27,31-32,36-45,55-56,64,68,77-79,81-85H,5-15,17-18,58-59H2,1-4H3,(H2,60,80)(H2,62,86)(H2,63,92)(H,65,69)(H,66,88)(H,67,89)(H,70,91)(H,74,87)(H,75,90)(H2,61,73,76)/t23-,24+,25+,26-,27-,31-,32+,36-,37-,38-,39+,40+,41-,42-,43-,44-,45-,55+,56-/m0/s1

InChIKey

QYOAUOAXCQAEMW-UTXKDXHTSA-N

LogP

-8.252980000000012

Topological Polar Surface Area

665.12 Å²

Hydrogen Bond Donor/Acceptor

28 / 40

Complexity

2620

Synonyms & References

English

11116-32-8
Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-
Pingyangmycin
Bleomycin A5
Bleomycetin
CHEBI:78160
Zhengguangmycin A5
Q27147663
SCHEMBL19891997
BLM A5
N1-[3-[(4-aminobutyl)amino]propyl]-
bleomycetin
N1-(3-((4-Aminobutyl)amino)propyl)bleomycinamide
Pingyangmycin A5
Zhengguanmycin
Bleomycinamide,N1-[3-[(4-aminobutyl)amino]propyl]
Zhengguanmycin A5
Nsc350895

MDL Number

MFCD00869290

FAQ

What are the physical and chemical properties of Bleomycin A5 (CAS: 11116-32-8)?

Bleomycin A5 (CAS: 11116-32-8) is a cyclic polyketide antibiotic with a molecular weight of approximately 1924 g/mol. It is insoluble in water but soluble in organic solvents like ethanol and dimethyl sulfoxide. Chemically, it exhibits oxidative reactivity and is known for its antitumor activity.

How is Bleomycin A5 (CAS: 11116-32-8) typically synthesized?

Bleomycin A5 (CAS: 11116-32-8) is synthesized through multi-step chemical reactions starting from dihydrostreptochinone. The synthesis involves various steps such as acetylation, epimerization, and cyclization, yielding a high purity product with a high selectivity and yield of about 50%.

What industries use Bleomycin A5 (CAS: 11116-32-8)?

Bleomycin A5 (CAS: 11116-32-8) is primarily used in the pharmaceutical industry for its antitumor properties. It is also explored in biotechnology for gene delivery and in medical research for cancer treatment studies.

What precautions should be taken when handling Bleomycin A5 (CAS: 11116-32-8)?

When handling Bleomycin A5 (CAS: 11116-32-8), it is essential to use personal protective equipment (PPE) such as gloves and goggles. Work should be conducted in a well-ventilated fume hood. In case of spill, immediately clean up using appropriate absorbent materials and follow local safety guidelines. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.