Ganciclovir sodium

Basic Information

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CAS Number

107910-75-8

Molecular Formula

C9H12N5NaO4

Molecular Weight

277.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

261-265°C

SMILES

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C1=NC2=C(N1COC(CO)CO)N=C(N=C2[O-])N.[Na+]

InChI

InChI=1S/C9H13N5O4.Na/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16;/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17);/q;+1/p-1

InChIKey

JJICLMJFIKGAAU-UHFFFAOYSA-M

LogP

-0.53920

Complexity

273

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

CS-0013616
Ganciclovir (as sodium)
6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, monosodium salt
DHPG Sodium
GANCICLOVIR SODIUM
Cytovene IV sodium
9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine, monosodium salt
JJICLMJFIKGAAU-UHFFFAOYSA-M
Q27231533
GCV Sodium
HY-13637A
D04301
sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate
SCHEMBL149822
107910-75-8
sodium 2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9H-purin-6-olate
6H-Purin-6-one, 1,9-dihydro-2-amino-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, monosodium salt
Ganciclovir sodium (USAN)
2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one sodium salt
MFCD00873979
GANCICLOVIR SODIUM (MART.)
DTXSID20883175
Cytovene-IV
RS-21592 sodium
6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, sodium salt
FT-0656038
J-002034
84245-13-6
CCG-267214
107910-75-8 (sodium)
Cytovene IV (TN)

MDL Number

MFCD00873979

Customs Code

2933990090

FAQ

What are the physical and chemical properties of Ganciclovir sodium (CAS: 107910-75-8)?

Ganciclovir sodium is a white to off-white crystalline powder with a molecular weight of approximately 404.46 g/mol. It is slightly soluble in water and ethanol. Ganciclovir sodium is relatively stable under normal conditions, but it can react with strong acids or bases to form inorganic salts. It has a specific melting point around 195-200°C and a pKa of approximately 3.6. The compound is generally stable at room temperature, but it should be stored in a cool, dry place away from direct sunlight.

How is Ganciclovir sodium (CAS: 107910-75-8) typically synthesized?

Ganciclovir sodium is synthesized through a multi-step process involving the condensation of 2'-deoxyuridine-5′-monophosphate with acyclovir. The reaction typically uses sodium hydride as a base, and the subsequent steps involve various hydrolysis, esterification, and alkylation reactions. The overall yield is around 50-60%, with the final step involving sodium hydroxide to form the sodium salt. The reaction conditions and purification steps are critical for achieving the desired selectivity and purity.

What industries use Ganciclovir sodium (CAS: 107910-75-8)?

Ganciclovir sodium is primarily used in the pharmaceutical industry for the treatment of viral infections, particularly cytomegalovirus (CMV) in immunocompromised patients such as those with AIDS or organ transplant recipients. Although it has limited applications in other industries, it is also used in some research and diagnostic applications due to its antiviral properties.

What precautions should be taken when handling Ganciclovir sodium (CAS: 107910-75-8)?

When handling Ganciclovir sodium (CAS: 107910-75-8), it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The compound should be handled in a fume hood to minimize inhalation risks. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials and disposed of according to local regulations. The safety data sheet (SDS) should be consulted for detailed handling and disposal instructions. Storage should be in a cool, dry place, away from direct sunlight and heat sources.