Ganciclovir sodium(CAS: 107910-75-8)

Ganciclovir sodium is a white to off-white crystalline powder with a molecular weight of approximately 404.46 g/mol. It is slightly soluble in water and ethanol. Ganciclovir sodium is relatively stable under normal conditions, but it can react with strong acids or bases to form inorganic salts. It has a specific melting point around 195-200°C and a pKa of approximately 3.6. The compound is generally stable at room temperature, but it should be stored in a cool, dry place away from direct sunlight.

Ganciclovir sodium is synthesized through a multi-step process involving the condensation of 2'-deoxyuridine-5′-monophosphate with acyclovir. The reaction typically uses sodium hydride as a base, and the subsequent steps involve various hydrolysis, esterification, and alkylation reactions. The overall yield is around 50-60%, with the final step involving sodium hydroxide to form the sodium salt. The reaction conditions and purification steps are critical for achieving the desired selectivity and purity.

Ganciclovir sodium is primarily used in the pharmaceutical industry for the treatment of viral infections, particularly cytomegalovirus (CMV) in immunocompromised patients such as those with AIDS or organ transplant recipients. Although it has limited applications in other industries, it is also used in some research and diagnostic applications due to its antiviral properties.

When handling Ganciclovir sodium (CAS: 107910-75-8), it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. The compound should be handled in a fume hood to minimize inhalation risks. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials and disposed of according to local regulations. The safety data sheet (SDS) should be consulted for detailed handling and disposal instructions. Storage should be in a cool, dry place, away from direct sunlight and heat sources.