N-(4-Nitrophenyl)acetamide

Basic Information

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CAS Number

104-04-1

Molecular Formula

C8H8N2O3

Molecular Weight

180.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

213.0 to 217.0 deg-C

Boiling Point

312.97°C (rough estimate)

Flash Point

408.9 °C at 760 mmHg

Solubility

2.2g/l

Refractive Index

1.6180 (estimate)

SMILES

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CC(=O)NC1=CC=C(C=C1)[N+](=O)[O-]

InChI

InChI=1S/C8H8N2O3/c1-6(11)9-7-2-4-8(5-3-7)10(12)13/h2-5H,1H3,(H,9,11)

InChIKey

NQRLPDFELNCFHW-UHFFFAOYSA-N

LogP

2.14940

Complexity

204

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Stability

Stable. Combustible. Incompatible with strong oxidizing agents.

Synonyms & References

English

Maybridge1_001346
4-(Acetylamino)nitrobenzene
PH3B066365
P-NITROACETANILIDE [MI]
CS-0128761
AI3-01545
N-(4-nitrophenyl)-acetamide
HMS545F04
N-Acetyl-4-nitroaniline
EINECS 203-169-0
1-Nitro-4-acetylaminobenzene;N-(4-nitrophenyl)acetamide
W-109385
4'-Nitroacetanilide
7E-925
N-(4-Nitro-phenyl)-acetamide
J-640230
doi:10.14272/NQRLPDFELNCFHW-UHFFFAOYSA-N
Q7041448
N-Acetyl-p-nitroaniline
SCHEMBL642700
WLN: WNR DMV1
4-Nitroacetanilide, 98%
P-Nitroacetanilide
p-Acetamidonitrobenzene
N-(p-Nitrophenyl)acetamide
Acetamide,N-(4-nitrophenyl)-
DTXSID5059290
N0108
J-800231
104-04-1
UNII-PH3B066365

MDL Number

MFCD00007303

Customs Code

2924299090

FAQ

What are the physical and chemical properties of N-(4-Nitrophenyl)acetamide (CAS: 104-04-1)?

N-(4-Nitrophenyl)acetamide (CAS: 104-04-1) is a white crystalline solid with a molecular weight of approximately 191.13 g/mol. It has a melting point of 122-124°C and is slightly soluble in water. It is stable under normal conditions but can react with strong bases to form 4-nitrophenol. It is also known to be sensitive to light and heat.

How is N-(4-Nitrophenyl)acetamide (CAS: 104-04-1) typically synthesized?

N-(4-Nitrophenyl)acetamide is typically synthesized by the acetylation of 4-nitrophenol using acetic anhydride in the presence of a catalyst such as pyridine. The reaction is carried out at room temperature, and the yield is generally around 85-90%. The product is then purified by recrystallization.

What industries use N-(4-Nitrophenyl)acetamide (CAS: 104-04-1)?

N-(4-Nitrophenyl)acetamide (CAS: 104-04-1) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also used in the polymer industry for the production of special resins and adhesives. Additionally, it is used in the development of sensors and semiconductors.

What precautions should be taken when handling N-(4-Nitrophenyl)acetamide (CAS: 104-04-1)?

When handling N-(4-Nitrophenyl)acetamide (CAS: 104-04-1), use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store the compound in a cool, dry place, away from direct sunlight and heat sources. Handle in a fume hood to avoid inhalation. In case of spills, neutralize with an appropriate alkali and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information.