Ethyl 2,4-dihydroxy-6-methylnicotinate

Basic Information

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CAS Number

10350-10-4

Molecular Formula

C9H11NO4

Molecular Weight

197.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

216-222°C

SMILES

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CCOC(=O)C1=C(C=C(NC1=O)C)O

InChI

InChI=1S/C9H11NO4/c1-3-14-9(13)7-6(11)4-5(2)10-8(7)12/h4H,3H2,1-2H3,(H2,10,11,12)

InChIKey

CMCZAWPDHHYFPU-UHFFFAOYSA-N

LogP

0.9779199999999997

Topological Polar Surface Area

79.65 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

341

Synonyms & References

English

FT-0694987
ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate
EN300-98599
3-Pyridinecarboxylicacid, 1,2-dihydro-4-hydroxy-6-methyl-2-oxo-, ethyl ester
ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydro-3-pyridinecarboxylate
CHEMBL1529758
SCHEMBL1062838
E0869
ETHYL 2,4-DIHYDROXY-6-METHYL-3-PYRIDINE-CARBOXYLATE
NSC-109231
Ethyl 4-hydroxy-6-methyl-2-oxo-1 pound not2-dihydropyridine-3-carboxylate
FT-0641278
2,4-Dihydroxy-6-methyl-3-pyridinecarboxylic Acid Ethyl Ester
Nicotinic acid, 1,2-dihydro-4-hydroxy-6-methyl-2-oxo-, ethyl ester
2,4-Dihydroxy-6-methyl-3-pyridine carboxylic acid ethyl ester
3-Pyridinecarboxylic acid, 1,2-dihydro-4-hydroxy-6-methyl-2-oxo-, ethyl ester
A9273
SY020959
Ethyl 2,4-dihydroxy-6-methylnicotinate, AldrichCPR
ethyl-4-hydroxy-6-methyl-2-pyridone-3-carboxylate
70254-52-3
ethyl 2,4-dihydroxy-6-methylpyridine-3-carboxylate
2,4-Dihydroxy-6-methylnicotinic Acid Ethyl Ester
ETHYL ESTER 2,4-DIHYDROXY-6-METHYL-3-PYRIDINE CARBOXYLIC ACID
10350-10-4
4-Hydroxy-6-methyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid ethyl ester
W-204499
3-Pyridinecarboxylic acid,2-dihydro-4-hydroxy-6-methyl-2-oxo-, ethyl ester
Ethyl 2,4-dihydroxy-6-methylnicotinate #
J-520670
HMS1432N04

MDL Number

MFCD02929397

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Ethyl 2,4-dihydroxy-6-methylnicotinate (CAS: 10350-10-4)?

Ethyl 2,4-dihydroxy-6-methylnicotinate is a white crystalline solid with a molecular weight of approximately 228.2 g/mol. It is slightly soluble in water and ethanol, but more soluble in organic solvents such as methanol and acetone. The compound exhibits moderate reactivity, particularly towards acid and base catalyzed reactions, and it is known for its stability under normal storage conditions.

How is Ethyl 2,4-dihydroxy-6-methylnicotinate (CAS: 10350-10-4) typically synthesized?

Ethyl 2,4-dihydroxy-6-methylnicotinate is typically synthesized through the condensation of 2,4-dihydroxybenzoic acid with ethylamine, followed by a methyl esterification step. This reaction is usually catalyzed by a strong acid such as sulfuric acid, and the yield is generally around 85-90%. The selectivity and purity of the product can be further improved through recrystallization techniques.

What industries use Ethyl 2,4-dihydroxy-6-methylnicotinate (CAS: 10350-10-4)?

Ethyl 2,4-dihydroxy-6-methylnicotinate finds applications in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also used in the development of sensors and semiconductors due to its specific chemical reactivity and stability. In the polymer industry, it can be utilized as a functional monomer or additive.

What precautions should be taken when handling Ethyl 2,4-dihydroxy-6-methylnicotinate (CAS: 10350-10-4)?

When handling Ethyl 2,4-dihydroxy-6-methylnicotinate, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be immediately cleaned up with appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.