Ethyl 2,4-dihydroxy-6-methylnicotinate(CAS: 10350-10-4)

Ethyl 2,4-dihydroxy-6-methylnicotinate is a white crystalline solid with a molecular weight of approximately 228.2 g/mol. It is slightly soluble in water and ethanol, but more soluble in organic solvents such as methanol and acetone. The compound exhibits moderate reactivity, particularly towards acid and base catalyzed reactions, and it is known for its stability under normal storage conditions.

Ethyl 2,4-dihydroxy-6-methylnicotinate is typically synthesized through the condensation of 2,4-dihydroxybenzoic acid with ethylamine, followed by a methyl esterification step. This reaction is usually catalyzed by a strong acid such as sulfuric acid, and the yield is generally around 85-90%. The selectivity and purity of the product can be further improved through recrystallization techniques.

Ethyl 2,4-dihydroxy-6-methylnicotinate finds applications in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also used in the development of sensors and semiconductors due to its specific chemical reactivity and stability. In the polymer industry, it can be utilized as a functional monomer or additive.

When handling Ethyl 2,4-dihydroxy-6-methylnicotinate, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be immediately cleaned up with appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.