Pantoprazole EP Impurity B (Pantoprazole USP Related Compound B, Pantoprazole Sulfide)

Basic Information

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CAS Number

102625-64-9

Molecular Formula

C16H15F2N3O3S

Molecular Weight

367.38 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

116.0 to 120.0 deg-C

Boiling Point

526.3°C at 760 mmHg

SMILES

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COC1=C(C(=NC=C1)CSC2=NC3=C(N2)C=C(C=C3)OC(F)F)OC

InChI

InChI=1S/C16H15F2N3O3S/c1-22-13-5-6-19-12(14(13)23-2)8-25-16-20-10-4-3-9(24-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21)

InChIKey

UKILEIRWOYBGEJ-UHFFFAOYSA-N

LogP

3.868800000000002

Topological Polar Surface Area

69.26 Å²

Hydrogen Bond Donor/Acceptor

1 / 6

Complexity

424

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

I11939
P2066
AC-8095
MFCD07368273
5-Difluoromethoxy-2-[(3,4-dimethoxy-2-pyridinyl) methyl]thio-1H-benzimidazole
BCP12247
6-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridyl)methylsulfanyl]-1H-benzimidazole;5-DIFLUOROMETHOXY-2-[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]THIO-1H-BENZIMIDAZOLE
5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazole
5-difluoromethoxy-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazole
5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]thio]benzimidazole
5-Difluoromethoxy-2-[(3,4-dimethoxy-2-pyridyl)methyl]thio-1H-benzimidazole
5-Difluoromethoxy-2-[(3,4-dimethoxy-2-pyridinyl)methyl]thio-1H-benzimidazole
SCHEMBL537800
UNII-BWZ6X03HIB
1H-Benzimidazole, 6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-
SCHEMBL13846375
5-(Difluoromethoxy)-2-[[(3,4-dimethoxypyridin-2-yl)methyl]sulphanyl]-1H-benzimidazole
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl) methyl]thio]-1H-benzimidazole
5-(Difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfanyl)-1H-benzimidazole
AMY40854
5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridyl)methyl)thio)-1H-benzimidazole
5-Difluoromethoxy-2-(((3,4-dimethoxy-2-pyridyl)methyl)thio)-1H-benzimidazole
L-Asparticacid hydrochloride
H-258/28
DTXSID30145418
Pantoprazole sodium sesquihydrate specified impurity B [EP]
PANTOPRAZOLE SODIUM SESQUIHYDRATE IMPURITY B [EP IMPURITY]
Q27274931
CS-W016749
1H-Benzimidazole, 6-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)thio)-

MDL Number

MFCD07368273

Customs Code

2942000000

FAQ

What is Pantoprazole EP Impurity B (CAS: 102625-64-9)?

Pantoprazole EP Impurity B (CAS: 102625-64-9) is a sulfide derivative of pantoprazole, a proton pump inhibitor used in pharmaceuticals. It has the molecular formula C16H18N4O2S2 and is characterized by its white to off-white crystalline appearance. This compound is commonly identified during drug quality control processes to ensure purity and compliance with regulatory standards.

What are the main uses of Pantoprazole EP Impurity B (CAS: 102625-64-9)?

Pantoprazole EP Impurity B (CAS: 102625-64-9) is primarily used in pharmaceutical research and quality control to detect and quantify impurities in pantoprazole formulations. It may also serve as a degradation product or byproduct in drug manufacturing. Its presence is critical for assessing the safety and efficacy of pharmaceutical products, particularly in adherence to USP and EP specifications.

Is Pantoprazole EP Impurity B (CAS: 102625-64-9) safe?

Pantoprazole EP Impurity B (CAS: 102625-64-9) is generally considered safe when handled according to standard laboratory protocols, but it requires caution. Limited toxicity data suggests it is less hazardous than the parent compound, but proper protective measures such as gloves and ventilation should be used. Safety standards under ICH guidelines emphasize monitoring its levels in drug products to ensure they remain within acceptable thresholds.

How should Pantoprazole EP Impurity B (CAS: 102625-64-9) be stored?

Pantoprazole EP Impurity B (CAS: 102625-64-9) should be stored in a sealed, light-resistant container at controlled room temperature (15-30°C) or refrigerated conditions (2-8°C) to maintain stability. It is sensitive to moisture and light, so desiccation and protection from humidity are essential. Storage should comply with chemical safety regulations to prevent degradation or contamination.