A portable multiple ionization source biological mass spectrometer
Literature Information
Jung-Lee Lin, Ming-Lee Chu, Chung-Hsuan Chen
In the past, matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI), used for large biomolecule detection, were usually installed in two separate mass spectrometers. In this study, they were equipped in the same mass spectrometer. This portable biological mass spectrometer has multiple ionization capabilities in the same mass spectrometer and shares the same mass analyzer and detector. This mass spectrometer can be operated under low vacuum (∼10–3 Torr) and can use air as the buffer gas. Therefore, the demand for pumping is reduced and rare gas feeding is no longer essential. A small scroll pump, employed to assist a miniature turbo pump, is sufficient to maintain the operational pressure. The mass spectra of biomolecules were obtained using frequency scanning instead of voltage ramping. Therefore, a wider mass-to-charge ratio (m/z) range was achieved. Furthermore, the design also couples a conversion dynode with a channeltron to enhance the mass detection range. This homemade mass spectrometer has the capability to measure charged particles with very large m/z values (m/z > 100 000). The concentrations of the studied compounds (angiotensin, insulin, cytochrome C, bovine serum albumin (BSA), immunoglobulin G, and immunoglobulin A) are from 5 femtomole to 100 picomole, and the mass resolutions are from 30 to 260. The mass range of this portable mass spectrometer was comparable with a commercial linear time-of-flight mass spectrometer owing to the use of the frequency scan.
Related Literature
Thermal optical non-linearity of nematic mesophase enhanced by gold nanoparticles – an experimental and numerical investigation
O. Kurochkin, Y. K. Murugesan, T. P. Bennett, G. D'Alessandro, Y. Reznikov, B. J. Tang, G. H. Mehl, M. Kaczmarek
DOI: 10.1039/C6CP00116E
Stable n-type doping of graphene via high-molecular-weight ethylene amines
Insu Jo, Joonhee Moon, Subeom Park, Jin San Moon, Won Bae Park, Jeong Soo Lee, Byung Hee Hong
DOI: 10.1039/C5CP03196F
Dielectric function of two-phase colloid–polymer nanocomposite
S. Mitzscherling, Q. Cui, W. Koopman
DOI: 10.1039/C5CP04326C
Co-operative motion of multiple benzoquinone disks at the air–water interface
Jennifer E. Satterwhite-Warden, Dilip K. Kondepudi
DOI: 10.1039/C5CP04471E
Decay rate of real space delocalization measures: a comparison between analytical and test systems
A. Gallo-Bueno, E. Francisco, A. Martín Pendás
DOI: 10.1039/C5CP06098B
Intraparticulate speciation analysis of soft nanoparticulate metal complexes. The impact of electric condensation on the binding of Cd2+/Pb2+/Cu2+ by humic acids
Raewyn M. Town, Herman P. van Leeuwen
DOI: 10.1039/C6CP01229A
Roles of the scalar and vector components of the solvation effects on the vibrational properties of hydrogen- or halogen-bond accepting stretching modes
Saori Noge
DOI: 10.1039/C5CP08008H
An intensive dispersion and synchronous assembly of single-walled carbon nanotubes in a surfactant–oil–water association system
Yan Zhang, Dechun Li, Lin Wu, Liang Zhou, Yanan Du, Meng Wang, Ying Li
DOI: 10.1039/C6CP00397D
Particularly strong C–H⋯π interactions between benzene and all-cis 1,2,3,4,5,6-hexafluorocyclohexane
Neil S. Keddie, Roberto Rittner, David O'Hagan, Michael Bühl
DOI: 10.1039/C5CP04537A
Fine-tuning of microsolvation and hydrogen bond interaction regulates substrate channelling in the course of flavonoid biosynthesis
Julien Diharce, Jérôme Golebiowski, Sébastien Fiorucci, Serge Antonczak
DOI: 10.1039/C5CP05059F
You might also like
How should waste containing 4-Bromo-3-methyl-2-thiophenecarboxylic acid (CAS: 265652-39-9) be handled?
Waste containing 4-Bromo-3-methyl-2-thiophenecarboxylic acid (CAS: 265652-39-9) ...
What industries use (2S,5S,2'S,5'S)-1,1'-(1,2-Ethanediyl)bis(2,5-dimethylphospholane) (CAS: 136779-26-5)?
(2S,5S,2'S,5'S)-1,1'-(1,2-Ethanediyl)bis(2,5-dimethylphospholane) is primarily u...
What industries use Ethyl 2-(2-bromo-5-fluorophenyl)acetate (CAS: 1214910-61-8)?
Ethyl 2-(2-bromo-5-fluorophenyl)acetate (CAS: 1214910-61-8) is used in the pharm...
How is 4-Methyl-2-benzofuran-1,3-dione (CAS: 4792-30-7) typically synthesized?
4-Methyl-2-benzofuran-1,3-dione (CAS: 4792-30-7) can be synthesized through seve...
What industries use 4,6-Dichloroquinoline-3-carbonitrile (CAS: 936498-04-3)?
4,6-Dichloroquinoline-3-carbonitrile (CAS: 936498-04-3) is used in the pharmaceu...
What are the main uses of Chloro[tris(para-trifluoromethylphenyl)phosphine]gold(I) (CAS: 385815-83-8)?
Chloro[tris(para-trifluoromethylphenyl)phosphine]gold(I) is primarily used in or...
Is 2-Bromo-5-nitrofuran (CAS: 823-73-4) safe?
2-Bromo-5-nitrofuran (CAS: 823-73-4) is generally considered safe when handled w...
How should 5-Bromo-2,3,4-trifluorobenzoic acid (CAS: 212631-85-1) be stored?
5-Bromo-2,3,4-trifluorobenzoic acid should be stored in a cool, dry place away f...
What are the main uses of Zinc bis(aminoacetate) (CAS: 7214-08-6)?
Zinc bis(aminoacetate) (CAS: 7214-08-6) is primarily used in the pharmaceutical ...
How should Adamantan-1-ylmethanol (CAS: 770-71-8) be stored?
Adamantan-1-ylmethanol should be stored in a cool, dry, and well-ventilated plac...
Source Journal
Analyst

Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.











![(4R,5S,6S)-3-({(3S,5S)-5-[(3-Carboxyphenyl)carbamoyl]-3-pyrrolidinyl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid structure (4R,5S,6S)-3-({(3S,5S)-5-[(3-Carboxyphenyl)carbamoyl]-3-pyrrolidinyl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid structure](https://static.chemtradehub.com/structs/153/153832-46-3-b2e0.webp)


