A rhodium-catalyzed three-component reaction of arylisocyanides, trifluorodiazoethane, and activated methylene isocyanides or azomethine ylides: an efficient synthesis of trifluoroethyl-substituted imidazoles
Literature Information
Publication Date
2019-09-17
DOI
10.1039/C9QO00856J
Impact Factor
5.281
Authors
Yang Yu, Yan Zhang, Zhuo Wang, Yong-Xin Liang, Yu-Long Zhao
View Original
Abstract
A rhodium-catalyzed three-component reaction of isocyanides, 2,2,2-trifluorodiazoethane and activated methylene isocyanides or azomethine ylides has been developed. In this transformation, the ketenimine intermediates generated by the coupling reaction of arylisocyanides with 2,2,2-trifluorodiazoethane undergo intermolecular [3 + 2] cyclization with activated methylene isocyanides or azomethine ylides and provide a new and highly efficient method for the construction of trifluoroethyl-substituted imidazoles in a single step.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
Oxalic acid compound with cyclohexylsulfamothioic O-acid (11)
CAS Number:
31895-22-4
Molecular Formula:
C7H13NO4S3
![5-Bromoimidazo[1,2-a]pyridine structure](https://static.chemtradehub.com/structs/692/69214-09-1-d8e2.webp "5-Bromoimidazo[1,2-a]pyridine structure")
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