3,3-Diazidoenones – new types of highly reactive bis-azides. Preparation and synthetic transformations
Literature Information
Publication Date
2018-12-10
DOI
10.1039/C8QO01214H
Impact Factor
5.281
Authors
Pavel S. Lemport, Ivan V. Smolyar, Victor N. Khrustalev, Vitaly A. Roznyatovsky, Alexander V. Popov, Valentina A. Kobelevskaya, Igor B. Rozentsveig, Valentine G. Nenajdenko
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Abstract
The interaction of geminal dichlorovinylketones with sodium azide was investigated by NMR and DFT calculations. It was found that the corresponding geminal 3,3-diazidoenones are the resultant species. These highly reactive compounds can be trapped with cyclooctyne to form bis-triazolyl substituted enones. In the absence of a trapping agent, 3,3-diazidoenones do cyclize into 3-azidoisoxazoles with the elimination of molecular nitrogen. The versatile reactivity of the resultant azidoisoxazoles was demonstrated in reactions with phosphorus(III) derivatives, Huisgen 1,3-dipolar cycloaddition and Dimroth cyclization to provide efficient access to a variety of valuable compounds.
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Organic Chemistry Frontiers
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